Tzelepis Elias G, Barengolts Elena, Garzon Steven, Shulan Joseph, Eisenberg Yuval
Division of Endocrinology, Diabetes & Metabolism, University of Illinois at Chicago, Chicago, IL, USA.
Department of Pathology, University of Illinois at Chicago, Chicago, IL, USA.
Case Rep Endocrinol. 2019 Mar 17;2019:7964126. doi: 10.1155/2019/7964126. eCollection 2019.
To present a rare case of malignant struma ovarii (MSO) and synchronous thyroid cancer, review the medical literature, and present the latest trends in management.
The case of a woman with MSO and concomitant thyroid cancer is presented, including clinical presentation, treatment, and follow-up care. A search of the English-language literature was conducted using MEDLINE and Google Scholar data bases.
We found 10 publications (one abstract) describing 10 patients with MSO and concomitant thyroid cancer. Six additional patients were reported by a study that analyzed the SEER (cancer registry) database. The median age of women was 42 years, with the majority of them presenting with abdominal symptoms. Histologically, most tumors were papillary carcinomas in both organs. In 5 patients, there was extrathyroidal tumor extension at time of surgery.
MSO can occasionally coexist with highly aggressive eutopic thyroid cancer. Although this concurrence is even rarer than MSO, clinicians should routinely investigate for possible synchronous thyroid cancer in all cases of MSO and also consider aggressive postoperative treatment including thyroidectomy and radioiodine ablation therapy in cases of MSO.
报告一例罕见的恶性卵巢甲状腺肿（MSO）合并甲状腺癌病例，回顾医学文献，并介绍最新的治疗趋势。
介绍一例患有MSO并伴有甲状腺癌的女性病例，包括临床表现、治疗及随访情况。使用MEDLINE和谷歌学术数据库对英文文献进行检索。
我们发现10篇出版物（1篇摘要）描述了10例患有MSO并伴有甲状腺癌的患者。一项分析SEER（癌症登记）数据库的研究报告了另外6例患者。女性的中位年龄为42岁，大多数患者表现为腹部症状。组织学上，两个器官中的大多数肿瘤均为乳头状癌。5例患者在手术时存在甲状腺外肿瘤扩展。
MSO偶尔可与侵袭性很强的原位甲状腺癌同时存在。尽管这种并存情况比MSO更为罕见，但临床医生应常规对所有MSO病例进行检查，以排查可能同时存在的甲状腺癌，对于MSO病例还应考虑积极的术后治疗，包括甲状腺切除术和放射性碘消融治疗。
