Departments of GI Endoscopy, 108 Central Hospital, Hanoi, Vietnam.
Departments of Molecular Biology, 108 Central Hospital, Hanoi, Vietnam.
Gut Liver. 2019 Sep 15;13(5):483-497. doi: 10.5009/gnl18137.
Antibiotic resistance is the most important factor leading to the failure of eradication regimens. This review focuses on the prevalence of primary and secondary resistance to clarithromycin, metronidazole, amoxicillin, levofloxacin, tetracycline, and multidrug in Vietnam. We searched the PubMed, EMBASE, Vietnamese National Knowledge Infrastructure, and Vietnamese Biomedical databases from January 2000 to December 2016. The search terms included the following: infection, antibiotic (including clarithromycin, metronidazole, amoxicillin, levofloxacin, tetracycline, and multidrug) resistance in Vietnam. The data were summarized in an extraction table and analyzed manually. Finally, Excel 2007 software was used to create charts. Ten studies (three studies in English and seven in Vietnamese) were included in this review. A total of 308, 412, 523, 408, 399, and 268 strains were included in this review to evaluate the prevalence of primary resistance to amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, and multidrug resistance, respectively. Overall, the primary resistance rates of amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, and multidrug resistance were 15.0%, 34.1%, 69.4%, 27.9%, 17.9% and 48.8%, respectively. Secondary resistance rates of amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, and multidrug resistance were 9.5%, 74.9%, 61.5%, 45.7%, 23.5% and 62.3%, respectively. In Vietnam, primary and secondary resistance to is increasing over time and affects the effectiveness of eradication.
抗生素耐药性是导致根除疗法失败的最重要因素。本综述重点关注越南克拉霉素、甲硝唑、阿莫西林、左氧氟沙星、四环素和多药耐药的原发性和继发性耐药的流行情况。我们在 2000 年 1 月至 2016 年 12 月期间在 PubMed、EMBASE、越南国家知识基础设施和越南生物医学数据库中搜索了以下术语：感染、抗生素（包括克拉霉素、甲硝唑、阿莫西林、左氧氟沙星、四环素和多药）耐药性在越南。数据汇总在提取表中，并手动进行分析。最后，使用 Excel 2007 软件创建图表。本综述共纳入 10 项研究（3 项英文研究，7 项越南文研究）。共纳入 308、412、523、408、399 和 268 株用于评估阿莫西林、克拉霉素、甲硝唑、左氧氟沙星、四环素和多药耐药的原发性耐药率。总体而言，阿莫西林、克拉霉素、甲硝唑、左氧氟沙星、四环素和多药耐药的原发性耐药率分别为 15.0%、34.1%、69.4%、27.9%、17.9%和 48.8%。阿莫西林、克拉霉素、甲硝唑、左氧氟沙星、四环素和多药耐药的继发性耐药率分别为 9.5%、74.9%、61.5%、45.7%、23.5%和 62.3%。在越南，原发性和继发性耐药性随着时间的推移而增加，影响了根除的效果。
