Department of Gastroenterology, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China 210019.
Comput Math Methods Med. 2022 Oct 11;2022:1221190. doi: 10.1155/2022/1221190. eCollection 2022.
The present study was designed to observe the effect of quadruple therapy combined with probiotics on -related peptic ulcer. The patients in the control group ( = 90) were given regular quadruple therapy including proton pump inhibitor ilaprazole enteric-coated tablet + two antibiotics amoxicillin dispersible tablet and metronidazole tablet + colloidal bismuth pectin capsule for 2 weeks. Patients in the study group ( = 90) were given abovementioned quadruple therapy combined with probiotics live combined , , and Capsules, oral for 2 weeks. Then Hp clearance rate, recurrence rate, levels of gastrointestinal hormone makers, and advance reactions between two groups were compared. At the 2nd week after the treatment, the clearance rate in the study group (87.79%) was significantly higher than the control group (78.89%), and the total recurrence rate in the study group (6.67%) was significantly lower than the control group (13.33%) ( < 0.05). Serum gastrin and motilin expression were lower, and somatostatin expressions was significantly higher than those in the control group ( < 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups ( > 0.05). In summary, quadruple therapy combined with probiotics in the treatment of -related peptic ulcer can improve the clearance rate, reduce the recurrence rate, and is beneficial to improving the level of gastrointestinal hormones, with certain safety.
本研究旨在观察四联疗法联合益生菌对相关消化性溃疡的治疗效果。对照组（n=90）给予常规四联疗法，包括质子泵抑制剂艾普拉唑肠溶片+两种抗生素阿莫西林分散片和甲硝唑片+胶体果胶铋胶囊，疗程 2 周。观察组（n=90）在上述四联疗法的基础上加用益生菌双歧杆菌三联活菌肠溶胶囊、，口服，疗程 2 周。比较两组 Hp 清除率、复发率、胃肠激素标志物水平及不良反应发生情况。治疗第 2 周末，观察组 Hp 清除率（87.79%）显著高于对照组（78.89%），观察组总复发率（6.67%）显著低于对照组（13.33%）（<0.05）。观察组血清胃泌素和胃动素表达降低，生长抑素表达升高，与对照组比较差异有统计学意义（<0.05）。两组不良反应总发生率比较差异无统计学意义（>0.05）。综上所述，四联疗法联合益生菌治疗相关消化性溃疡可提高 Hp 清除率，降低复发率，有利于改善胃肠激素水平，且具有一定安全性。
