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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Newman J D, Farley M J

Laboratory of Comparative Ethology, NICHD, NIH, Poolesville, MD, USA.

Prog Neuropsychopharmacol Biol Psychiatry. 1995 Jul;19(4):677-85. doi: 10.1016/0278-5846(95)00111-8.

Adult male and female squirrel monkeys were tested for behavioral responses to 5 min. social separation (alone in test room) followed by 30-sec. exposure to 2 humans wearing a leather capture glove. 2. Trials were preceded by intramuscular injection of an anticholinergic drug, benactyzine hydrochloride, in doses of 0.0, 0.6, 1.0, 2.0, and 3.0 mg/kg. 3. Measured behaviors were number and type of vocalization and locomotor activity (duration in sec) in each of the two testing conditions. 4. A dose-response relationship for bark/yap vocalizations during the 30-sec trials was established, with 1.0 mg/kg being the most effective dose. 5. Males and females differed in the number of barks/yaps produced during 30-sec. trials at every drug dose. 6. The present testing paradigm provides the basis for efficiently determining the extent of gender differences in dose/response relationships for drugs of possible therapeutic value in the treatment of anxiety-related behavioral disorders.

对成年雄性和雌性松鼠猴进行了测试，观察它们在5分钟社交隔离（单独置于测试室）后，再与两名戴着皮制捕捉手套的人接触30秒的行为反应。2. 在试验前，通过肌肉注射抗胆碱能药物盐酸苯乃嗪，剂量分别为0.0、0.6、1.0、2.0和3.0毫克/千克。3. 所测量的行为包括在两种测试条件下的发声次数和类型以及运动活动（以秒为单位的持续时间）。4. 建立了30秒试验期间吠叫/尖叫发声的剂量反应关系，1.0毫克/千克是最有效的剂量。5. 在每个药物剂量的30秒试验中，雄性和雌性发出的吠叫/尖叫次数存在差异。6. 目前的测试范式为有效确定在治疗焦虑相关行为障碍方面可能具有治疗价值的药物的剂量/反应关系中性别差异的程度提供了基础。

Newman J D, Farley M J

Laboratory of Comparative Ethology, NICHD, NIH, Poolesville, MD, USA.

Prog Neuropsychopharmacol Biol Psychiatry. 1995 Jul;19(4):677-85. doi: 10.1016/0278-5846(95)00111-8.

Adult male and female squirrel monkeys were tested for behavioral responses to 5 min. social separation (alone in test room) followed by 30-sec. exposure to 2 humans wearing a leather capture glove. 2. Trials were preceded by intramuscular injection of an anticholinergic drug, benactyzine hydrochloride, in doses of 0.0, 0.6, 1.0, 2.0, and 3.0 mg/kg. 3. Measured behaviors were number and type of vocalization and locomotor activity (duration in sec) in each of the two testing conditions. 4. A dose-response relationship for bark/yap vocalizations during the 30-sec trials was established, with 1.0 mg/kg being the most effective dose. 5. Males and females differed in the number of barks/yaps produced during 30-sec. trials at every drug dose. 6. The present testing paradigm provides the basis for efficiently determining the extent of gender differences in dose/response relationships for drugs of possible therapeutic value in the treatment of anxiety-related behavioral disorders.

对成年雄性和雌性松鼠猴进行了测试，观察它们在5分钟社交隔离（单独置于测试室）后，再与两名戴着皮制捕捉手套的人接触30秒的行为反应。2. 在试验前，通过肌肉注射抗胆碱能药物盐酸苯乃嗪，剂量分别为0.0、0.6、1.0、2.0和3.0毫克/千克。3. 所测量的行为包括在两种测试条件下的发声次数和类型以及运动活动（以秒为单位的持续时间）。4. 建立了30秒试验期间吠叫/尖叫发声的剂量反应关系，1.0毫克/千克是最有效的剂量。5. 在每个药物剂量的30秒试验中，雄性和雌性发出的吠叫/尖叫次数存在差异。6. 目前的测试范式为有效确定在治疗焦虑相关行为障碍方面可能具有治疗价值的药物的剂量/反应关系中性别差异的程度提供了基础。