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人类主动脉粥样硬化病变中的内皮纤毛

Endothelial cilia in human aortic atherosclerotic lesions.

作者信息

Haust M D

出版信息

Virchows Arch A Pathol Anat Histopathol. 1987;410(4):317-26. doi: 10.1007/BF00711288.

DOI:10.1007/BF00711288
PMID:3101281
Abstract

"Primary" cilia were present in the endothelial cells of human aortic fatty dots and streaks but not in those of normal intima. They had the features of cilia of the "9 + 0" axonemal configuration observed in many other cells. A lateral foot process and transitional fibers "anchored" the ciliary basal body in the cytoplasm, but rootlets were not identified in material examine. Ladder-like configurations interconnected the two centrioles (= diplosome) of control endothelium. The "primary" cilia of endothelium differed from those of the rudimentary type observed in smooth muscle cells in similar lesions of man, but shared many features with cilia of those present in experimental atherosclerosis in rabbit. Cilia were rarely described in vascular endothelium. It is believed that, to date, they were not reported to occur in normal or pathological arteries in man. It is being stressed that whereas the significance of these unusual organelles remains uncertain, their widespread occurrence may indicate that their role is more important than was believed previously, and they should cease being a curiosity only.

摘要

“原发性”纤毛存在于人类主动脉脂肪斑和条纹的内皮细胞中,而正常内膜的内皮细胞中则没有。它们具有在许多其他细胞中观察到的“9 + 0”轴丝结构的纤毛特征。一个外侧足突和过渡纤维将纤毛基体“锚定”在细胞质中,但在所检查的材料中未发现根丝。梯状结构连接了对照内皮的两个中心粒(=二联体)。内皮细胞的“原发性”纤毛与在人类类似病变的平滑肌细胞中观察到的原始类型的纤毛不同,但与兔实验性动脉粥样硬化中存在的纤毛有许多共同特征。血管内皮中很少描述有纤毛。据信,迄今为止,尚未报道它们在人类正常或病理动脉中出现。需要强调的是,尽管这些不寻常细胞器的意义仍不确定,但它们的广泛存在可能表明它们的作用比以前认为的更为重要,而且它们不应仅仅被视为一种奇闻。

相似文献

1
Endothelial cilia in human aortic atherosclerotic lesions.人类主动脉粥样硬化病变中的内皮纤毛
Virchows Arch A Pathol Anat Histopathol. 1987;410(4):317-26. doi: 10.1007/BF00711288.
2
Ciliated smooth muscle cells in atherosclerotic lesions of human aorta.人类主动脉粥样硬化病变中的纤毛平滑肌细胞。
Am J Cardiovasc Pathol. 1987 Jan;1(1):115-29.
3
Ciliated smooth muscle cells in aortic atherosclerotic lesions of rabbit.兔主动脉粥样硬化病变中的纤毛平滑肌细胞。
Atherosclerosis. 1984 Mar;50(3):283-93. doi: 10.1016/0021-9150(84)90076-5.
4
[The structure of the centriolar apparatus of the endothelial cells in the embryonic and definitive human aorta].[胚胎期及成年期人类主动脉内皮细胞中心粒装置的结构]
Ontogenez. 1988 Jul-Aug;19(4):371-9.
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Primary cilia of the corneal endothelium.角膜内皮细胞的初级纤毛。
Am J Anat. 1980 Dec;159(4):475-84. doi: 10.1002/aja.1001590410.
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Ciliation of bovine aortic endothelial cells in culture.培养的牛主动脉内皮细胞的纤毛形成
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Aortic endothelial cell morphology observed in situ by scanning electron microscopy during atherogenesis in the rabbit.在兔动脉粥样硬化形成过程中,通过扫描电子显微镜对主动脉内皮细胞形态进行原位观察。
Atherosclerosis. 1977 Jun;27(2):235-51. doi: 10.1016/0021-9150(77)90061-2.
8
Transitional features in human atherosclerosis. Intimal thickening, cholesterol clefts, and cell loss in human aortic fatty streaks.人类动脉粥样硬化中的过渡特征。人类主动脉脂肪条纹中的内膜增厚、胆固醇裂隙和细胞丢失。
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Acta Anat (Basel). 1995;153(2):85-95. doi: 10.1159/000147718.
10
Immunolocalization of centriole-associated striated rootlets in human submandibular gland cells with and without solitary cilia.有和没有单根纤毛的人下颌下腺细胞中中心粒相关横纹小根的免疫定位。
Histochem J. 2001 Nov-Dec;33(11-12):613-20. doi: 10.1023/a:1016346116017.

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Endothelial cilia dysfunction in pathogenesis of hereditary hemorrhagic telangiectasia.遗传性出血性毛细血管扩张症发病机制中的内皮细胞纤毛功能障碍
Front Cell Dev Biol. 2022 Nov 10;10:1037453. doi: 10.3389/fcell.2022.1037453. eCollection 2022.
2
Primary Cilia and Atherosclerosis.原发性纤毛与动脉粥样硬化
Front Physiol. 2021 Feb 2;12:640774. doi: 10.3389/fphys.2021.640774. eCollection 2021.
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Collateral Vessels Have Unique Endothelial and Smooth Muscle Cell Phenotypes.侧支血管具有独特的内皮和平滑肌细胞表型。

本文引用的文献

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Cilia in different segments of the rat nephron.大鼠肾单位不同节段的纤毛
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