de Veras Bruno Oliveira, Dos Santos Yago Queiroz, Oliveira Fernanda Granja da Silva, Almeida Jackson Roberto Guedes da Silva, da Silva Alexandre Gomes, Correia Maria Tereza Dos Santos, Diniz Katharina Marques, de Oliveira João Ricardhis Saturnino, Lima Vera Lúcia de Menezes, Navarro Daniela Maria do Amaral Ferraz, de Aguiar Júlio César Ribeiro de Oliveira Farias, de Oliveira Maria Betânia Melo, Lopes Ana Catarina de Souza, da Silva Márcia Vanusa
Department of Medicine Tropical, Federal University of Pernambuco, Recife, Brazil.
Department of Biochemistry, Federal University of Rio Grande do Norte, Fortaleza, Brazil.
Nat Prod Res. 2020 Oct;34(20):3013-3017. doi: 10.1080/14786419.2019.1602832. Epub 2019 Apr 23.
This work aimed to investigate the chemical composition, antimicrobial, antinociceptive, acute toxicity and antioxidant activity of the essential oil of (EOAm). The essential oil presented as the major constituents β-Pinene (56.99%), α-Pinene (16.57%), Germacrene D (4.67%), Bicyclogermacrene (4.66%), (E)-Caryophyllene (3.76%) and Limonene (1.71%). It was verified that the essential oil did not show acute toxicity in the maximum dose of 5,000 mg/kg. In the evaluation of the antinociceptive activity it was verified that the essential oil reduced in 65.84% the number of writhing in the mice, reducing the pain in 59.17%, and the mechanism of action in pain reduction was opioid, similar to morphine. The essential oil also presented significant antimicrobial against Gram positive and Gram-negative bacteria and fungi, and the antioxidant activity was relevant. Therefore, these results demonstrate the great potential for the future development of pharmaceutical products with the essential oil of .[Figure: see text].
本研究旨在调查[植物名称]精油（EOAm）的化学成分、抗菌、抗伤害感受、急性毒性和抗氧化活性。该精油的主要成分包括β-蒎烯（56.99%）、α-蒎烯（16.57%）、吉马烯D（4.67%）、双环吉马烯（4.66%）、（E）-石竹烯（3.76%）和柠檬烯（1.71%）。结果证实，该精油在最大剂量5000mg/kg时未表现出急性毒性。在抗伤害感受活性评估中，发现该精油可使小鼠扭体次数减少65.84%，疼痛减轻59.17%，其减轻疼痛的作用机制为阿片样，与吗啡相似。该精油对革兰氏阳性菌、革兰氏阴性菌和真菌也具有显著的抗菌活性，且具有相关的抗氧化活性。因此，这些结果表明[植物名称]精油在未来药品开发方面具有巨大潜力。[图：见正文]
