Raygor Viraj, Abbasi Fahim, Lazzeroni Laura C, Kim Sun, Ingelsson Erik, Reaven Gerald M, Knowles Joshua W
1 Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
2 Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Diab Vasc Dis Res. 2019 Mar;16(2):153-159. doi: 10.1177/1479164118813890.
Insulin sensitivity affects plasma triglyceride concentration and both differ by race/ethnicity. The purpose of this study was to provide a comprehensive assessment of the variation in insulin sensitivity and its relationship to hypertriglyceridaemia between five race/ethnic groups.
In this cross-sectional study, clinical data for 1025 healthy non-Hispanic White, Hispanic White, East Asian, South Asian and African American individuals were analysed. Insulin-mediated glucose disposal (a direct measure of peripheral insulin sensitivity) was measured using the modified insulin suppression test. Statistical analysis was performed using analysis of co-variance.
Of the study participants, 63% were non-Hispanic White, 9% were Hispanic White, 11% were East Asian, 11% were South Asian and 6% were African American. Overall, non-Hispanic Whites and African Americans displayed greater insulin sensitivity than East Asians and South Asians. Triglyceride concentration was positively associated with insulin resistance in all groups, including African Americans. Nevertheless, for any given level of insulin sensitivity, African Americans had the lowest triglyceride concentrations.
Insulin sensitivity, as assessed by a direct measure of insulin-mediated glucose disposal, and its relationship to triglyceride concentration vary across five race/ethnic groups. Understanding these relationships is crucial for accurate cardiovascular risk stratification and prevention.
胰岛素敏感性影响血浆甘油三酯浓度，且两者均因种族/民族而异。本研究的目的是全面评估五个种族/民族群体中胰岛素敏感性的差异及其与高甘油三酯血症的关系。
在这项横断面研究中，分析了1025名健康的非西班牙裔白人、西班牙裔白人、东亚人、南亚人和非裔美国人的临床数据。使用改良的胰岛素抑制试验测量胰岛素介导的葡萄糖处置（外周胰岛素敏感性的直接指标）。采用协方差分析进行统计分析。
在研究参与者中，63%为非西班牙裔白人，9%为西班牙裔白人，11%为东亚人，11%为南亚人，6%为非裔美国人。总体而言，非西班牙裔白人和非裔美国人的胰岛素敏感性高于东亚人和南亚人。在所有群体中，包括非裔美国人，甘油三酯浓度与胰岛素抵抗呈正相关。然而，对于任何给定的胰岛素敏感性水平，非裔美国人的甘油三酯浓度最低。
通过直接测量胰岛素介导的葡萄糖处置评估的胰岛素敏感性及其与甘油三酯浓度的关系在五个种族/民族群体中有所不同。了解这些关系对于准确的心血管风险分层和预防至关重要。
