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碳点:在生物成像和治疗中的应用。

Carbon dots: Applications in bioimaging and theranostics.

机构信息

Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China; Australian Institute for Bioengineering & Nanotechnology, The University of Queensland, St Lucia, Brisbane, QLD 4072, Australia.

出版信息

Int J Pharm. 2019 Jun 10;564:308-317. doi: 10.1016/j.ijpharm.2019.04.055. Epub 2019 Apr 20.

Abstract

Carbon dots are a carbonaceous nanomaterial that were discovered accidentally and are now drawing significant attention as a new quantum-sized fluorescent nanoparticle. Carbon dots are biocompatible, non-toxic, photostable, and easily functionalized with good photoluminescence and water solubility. Due to these unique properties, they are used broadly in live cell imaging, catalysis, electronics, biosensing, power, targeted drug delivery, and other biomedical applications. Here, we review the recent development of carbon dots in nanomedicine from their use in drug carriers to imaging agents to multifunctional theranostic systems. Finally, we discuss the challenges and views on next-generation carbon dot-based theranostics for clinical applications.

摘要

碳点是一种碳质纳米材料,是偶然发现的,现在作为一种新型量子荧光纳米粒子引起了广泛关注。碳点具有生物相容性、无毒、光稳定性好、易于功能化、具有良好的光致发光和水溶性。由于这些独特的性质,它们被广泛应用于活细胞成像、催化、电子、生物传感、能源、靶向药物输送和其他生物医学应用。在这里,我们从药物载体到成像剂再到多功能治疗系统,综述了碳点在纳米医学中的最新发展。最后,我们讨论了基于下一代碳点的治疗学用于临床应用的挑战和观点。

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