Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Biosci Rep. 2019 May 14;39(5). doi: 10.1042/BSR20182370. Print 2019 May 31.
MiR-19a was aberrantly expressed in various types of cancers and was observed to be potentially associated with the prognosis of cancer patients. The present analysis aims to elucidate its precise predictive value in various human malignancies. Online electronic searches of PubMed, Web of Science (WOS), Embase in English and VIP, Wanfang, SinoMed, and the China National Knowledge Infrastructure (CNKI) in Chinese up to September 8, 2018 were conducted. As a result, in overall analysis, a significant association was identified between miR-19a levels and OS (HRs = 2.31, CI: 1.11-4.83). The relation of miR-19a expression to OS was further recognized by fixed model within the studies of sample size less than 150 (HRs = 1.68, CI: 1.35-2.08), NOS scores greater than or equal to 8 (HRs = 1.53, CI: 1.13-2.06) or less than 8 (HRs = 1.89, CI: 1.58-2.27), specimen derived from tumor (HRs = 1.73, CI: 1.42-2.12) or blood (HRs = 1.87, CI: 1.46-2.40) and the patients of osteosarcoma (HRs = 7.17, CI: 5.04-10.21). Sensitivity analyses revealed no significant results. The association between miR-19a expression level and DFS was also found to be significant (HRs = 2.03, CI: 1.13-3.66). Correlations between miR-19a levels and clinicopathological features were examined and revealed that lymph node metastasis was significantly associated with miR-19a expression levels (OR = 0.565, CI: 0.346-0.921). Summarily, the over expression of miR-19a was an underlying risk of poor prognosis in many human malignancies, especially in osteosarcoma. Moreover, elevated miR-19a expression was linked to the potential of lymph node metastasis.
miR-19a 在多种类型的癌症中表达异常，并且观察到其与癌症患者的预后可能相关。本分析旨在阐明其在各种人类恶性肿瘤中的精确预测价值。以英文在线检索 PubMed、Web of Science(WOS)、Embase 和中文的维普、万方、中国生物医学文献数据库（CBM）、中国知网（CNKI），检索时限均为 2018 年 9 月 8 日。总体分析结果显示，miR-19a 水平与 OS 之间存在显著相关性（HRs=2.31，95%CI：1.11-4.83）。在样本量小于 150 的研究中，采用固定模型进一步确认 miR-19a 表达与 OS 的关系（HRs=1.68，95%CI：1.35-2.08），或在 NOS 评分大于或等于 8（HRs=1.53，95%CI：1.13-2.06）或小于 8（HRs=1.89，95%CI：1.58-2.27）、来源于肿瘤（HRs=1.73，95%CI：1.42-2.12）或血液（HRs=1.87，95%CI：1.46-2.40）的标本或骨肉瘤患者（HRs=7.17，95%CI：5.04-10.21）中，miR-19a 表达与 OS 之间存在显著相关性。敏感性分析结果无显著差异。miR-19a 表达水平与 DFS 之间也存在显著相关性（HRs=2.03，95%CI：1.13-3.66）。还检查了 miR-19a 水平与临床病理特征之间的相关性，结果表明淋巴结转移与 miR-19a 表达水平显著相关（OR=0.565，95%CI：0.346-0.921）。综上所述，miR-19a 的过表达是许多人类恶性肿瘤不良预后的潜在危险因素，尤其是骨肉瘤。此外，miR-19a 表达水平升高与淋巴结转移的可能性有关。
