Liu Yuhan, He Anbang, Liu Baoer, Huang Zhengxian, Mei Hongbing
Department of Urology, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen 518000, China.
Department of Urology, Peking University First Hospital, The Institute of Urology, Peking University, National Urological Cancer Centre, Beijing 100034, China.
Biomed Res Int. 2019 Mar 19;2019:9056458. doi: 10.1155/2019/9056458. eCollection 2019.
Long noncoding RNAs (lncRNAs) have been reported to serve as diagnostic and prognostic biomarkers of cancers, which play vital roles in tumorigenesis and tumor progression. Several studies have been performed to explore diagnostic value of lncRNA H19 in cancer detection and diagnosis. However, there are still inconsistent results in diagnostic accuracy and reliability in individual studies. Therefore, the present study was performed to summarize the overall diagnostic performance of lncRNA H19 in cancer detection and diagnosis. A total of eight studies with 770 cases and 815 controls were included in this pooled analysis. The pooled diagnostic results were as follows: sensitivity, 0.69 (95%CI=0.62-0.76), specificity, 0.79 (95% CI=0.70-0.86), positive likelihood ratio (PLR), 3.31 (95%CI=2.29-4.78), negative likelihood (NLR), 0.39 (95%CI=0.31-0.49), diagnostic odds ratio (DOR), 8.53 (95%CI=4.99-14.60), and area under the curve (AUC), 0.79 (95%CI=0.76-0.83). Deeks' funnel plot asymmetry test (P=0.13) suggested no potential publication bias. Our results indicated that lncRNA H19 had a relatively moderate accuracy in cancer detection and diagnosis. Further comprehensive prospective studies with large sample sizes are urgently required to validate our findings.
据报道，长链非编码RNA（lncRNAs）可作为癌症的诊断和预后生物标志物，在肿瘤发生和肿瘤进展中发挥重要作用。已经进行了多项研究来探索lncRNA H19在癌症检测和诊断中的诊断价值。然而，个别研究在诊断准确性和可靠性方面仍存在不一致的结果。因此，本研究旨在总结lncRNA H19在癌症检测和诊断中的总体诊断性能。本荟萃分析共纳入八项研究，涉及770例病例和815例对照。汇总诊断结果如下：敏感性为0.69（95%CI=0.62-0.76），特异性为0.79（95%CI=0.70-0.86），阳性似然比（PLR）为3.31（95%CI=2.29-4.78），阴性似然比（NLR）为0.39（95%CI=0.31-0.49），诊断比值比（DOR）为8.53（95%CI=4.99-14.60），曲线下面积（AUC）为0.79（95%CI=0.76-0.83）。Deeks漏斗图不对称检验（P=0.13）表明无潜在发表偏倚。我们的结果表明，lncRNA H19在癌症检测和诊断中具有相对中等的准确性。迫切需要进一步开展大样本量的全面前瞻性研究来验证我们的发现。
