Department of Emergency surgery, Department of Emergency Medicine, The First Affiliated Hospital of Anhui Medical University, Heifei, China.
Department of Radiation Oncology, The First Affiliated Hospital of Anhui Medical University, Heifei, China.
Biomark Med. 2020 Apr;14(5):401-411. doi: 10.2217/bmm-2019-0207. Epub 2020 Apr 9.
Numerous studies have investigated the diagnostic role of long noncoding RNA HOX transcript antisense RNA in cancers, but its diagnostic efficacy is inconsistent. The PubMed, Embase, Web of Science and Cochrane Library databases are used to retrieve relevant studies. The bivariate effect model was used to compute the combined sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and area under the receiver operating characteristic curve. A total of 13 studies were included in this meta-analysis. The combined sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and area under the receiver operating characteristic curve were: 0.77, 0.83, 4.7, 0.28, 17 and 0.87, respectively. Deeks' funnel plot test (p = 0.103) indicated no publication bias. Long noncoding RNA HOX transcript antisense RNA may be a useful biomarker for cancer detection.
大量研究已经探讨了长链非编码 RNA HOX 转录反义 RNA 在癌症中的诊断作用，但其实验结果并不一致。本研究检索了 PubMed、Embase、Web of Science 和 Cochrane Library 数据库中的相关研究。采用双变量效应模型计算合并后的敏感度、特异度、阳性似然比、阴性似然比、诊断比值比和受试者工作特征曲线下面积。本 meta 分析共纳入 13 项研究。合并后的敏感度、特异度、阳性似然比、阴性似然比、诊断比值比和受试者工作特征曲线下面积分别为：0.77、0.83、4.7、0.28、17 和 0.87。Deeks 漏斗图检验（p = 0.103）表明不存在发表偏倚。长链非编码 RNA HOX 转录反义 RNA 可能是一种用于癌症检测的有用生物标志物。
