Department of Pharmacology and Toxicology , National Institute of Pharmaceutical Education and Research (NIPER) , Ahmedabad, Gandhinagar , Gujarat 382355 , India.
Cellular and Molecular Neurobiology Laboratory, Department of Life Science and Bioinformatics , Assam University , Silchar , Assam 788011 , India.
ACS Chem Neurosci. 2019 Jun 19;10(6):2629-2646. doi: 10.1021/acschemneuro.9b00158. Epub 2019 May 6.
Calreticulin (CALR), a lectin-like ER chaperone, was initially known only for its housekeeping function, but today it is recognized for many versatile roles in different compartments of a cell. Apart from canonical roles in protein folding and calcium homeostasis, it performs a variety of noncanonical roles, mostly in CNS development. In the past, studies have linked Calreticulin with various other biological components which are detrimental in deciding the fate of neurons. Many neurological disorders that differ in their etiology are commonly associated with aberrant levels of Calreticulin, that lead to modulation of apoptosis and phagocytosis, and impact on transcriptional pathways, impairment in proteostatis, and calcium imbalances. Such multifaceted properties of Calreticulin are the reason why it has been implicated in vital roles of the nervous system in recent years. Hence, understanding its role in the physiology of neurons would help to unearth its involvement in the spectrum of neurological disorders. This Review aims toward exploring the interplay of Calreticulin in neurological disorders which would aid in targeting Calreticulin for developing novel neurotherapeutics.
钙网织蛋白（CALR）是一种类似凝集素的内质网伴侣蛋白，最初仅因其管家功能而被人们所知，但如今已被人们认识到它在细胞不同隔室中具有多种多功能的作用。除了在蛋白质折叠和钙稳态中的典型作用外，它还具有多种非典型作用，主要在中枢神经系统发育中发挥作用。过去的研究已经将钙网织蛋白与其他各种对神经元命运起决定作用的有害生物成分联系起来。许多病因不同的神经疾病通常与钙网织蛋白水平异常有关，导致细胞凋亡和吞噬作用的调节，并影响转录途径、蛋白质稳态的损害和钙失衡。钙网织蛋白的这种多方面特性是其近年来在神经系统重要作用中被牵涉的原因。因此，了解其在神经元生理学中的作用将有助于揭示其在一系列神经疾病中的参与。这篇综述旨在探讨钙网织蛋白在神经疾病中的相互作用，这将有助于针对钙网织蛋白开发新的神经治疗药物。
