DNA 编码文库的化学组成：过去、现在和未来。
Chemical composition of DNA-encoded libraries, past present and future.
机构信息
Department of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA.
出版信息
Org Biomol Chem. 2019 May 15;17(19):4676-4688. doi: 10.1039/c9ob00581a.
Abstract
DNA-encoded libraries represent an exciting and powerful modality for high-throughput screening. In this article, we highlight recent important advances in this field and also suggest some important directions that would make the technology even more powerful.
摘要
DNA 编码文库代表了高通量筛选的一种令人兴奋和强大的模式。在本文中，我们重点介绍了该领域的一些最新重要进展，并提出了一些将使该技术更加强大的重要方向。
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本文引用的文献
1
DNA Barcoding a Complete Matrix of Stereoisomeric Small Molecules.
J Am Chem Soc. 2019 Jul 3;141(26):10225-10235. doi: 10.1021/jacs.9b01203. Epub 2019 Jun 25.
2
A DNA-Encoded Chemical Library Incorporating Elements of Natural Macrocycles.
Angew Chem Int Ed Engl. 2019 Jul 8;58(28):9570-9574. doi: 10.1002/anie.201902513. Epub 2019 Jun 6.
3
DNA-Compatible [3 + 2] Nitrone-Olefin Cycloaddition Suitable for DEL Syntheses.
Org Lett. 2019 Mar 1;21(5):1325-1330. doi: 10.1021/acs.orglett.9b00017. Epub 2019 Feb 14.
4
Open-Air Alkylation Reactions in Photoredox-Catalyzed DNA-Encoded Library Synthesis.
J Am Chem Soc. 2019 Feb 27;141(8):3723-3732. doi: 10.1021/jacs.9b00669. Epub 2019 Feb 12.
5
Synthesis of Enantiomerically Pure 3-Substituted Piperazine-2-acetic Acid Esters as Intermediates for Library Production.
J Org Chem. 2018 Oct 5;83(19):11777-11793. doi: 10.1021/acs.joc.8b01708. Epub 2018 Sep 18.
6
Employing Photoredox Catalysis for DNA-Encoded Chemistry: Decarboxylative Alkylation of α-Amino Acids.
ChemMedChem. 2018 Oct 22;13(20):2159-2165. doi: 10.1002/cmdc.201800492. Epub 2018 Aug 23.
7
A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition.
ChemMedChem. 2018 Jul 6;13(13):1303-1307. doi: 10.1002/cmdc.201800193. Epub 2018 Jun 1.
8
Synthesis of Enantiomerically Pure 6-Substituted-Piperazine-2-Acetic Acid Esters as Intermediates for Library Production.
J Org Chem. 2018 Jun 15;83(12):6541-6555. doi: 10.1021/acs.joc.8b00854. Epub 2018 Jun 6.
9
Cyclization of peptides with two chemical bridges affords large scaffold diversities.
Nat Chem. 2018 Jul;10(7):715-723. doi: 10.1038/s41557-018-0042-7. Epub 2018 Apr 30.
10
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