Division of Molecular Medicine, Bose Institute, Kolkata, India.
Ann N Y Acad Sci. 2019 May;1443(1):54-74. doi: 10.1111/nyas.14027. Epub 2019 Apr 24.
The role of the evolutionarily conserved Wnt signaling pathway is well documented in several cellular processes, such as cell proliferation, differentiation, cell motility, and maintenance of the stem cell niche. The very first indication that aberrant Wnt signaling can cause carcinogenesis came from a finding that the mutation of the adenomatous polyposis coli gene (APC) predisposes a person to colorectal carcinoma. Later, with progressing research it became clear that abnormal activation or mutation of the genes related to this pathway could drive tumorigenesis. Here, we review recent advances in research regarding Wnt signaling regulation and its role in several cancer subtypes. Additionally, the utility of Wnt pathway-targeted cancer therapy intervention is also highlighted, with an overview of current approaches to target the Wnt pathway in oncogenesis and the future scopes and challenges associated with them.
Wnt 信号通路的进化保守作用在许多细胞过程中得到了很好的证明，例如细胞增殖、分化、细胞迁移和干细胞龛的维持。异常的 Wnt 信号能导致癌变的第一个迹象来自于发现腺瘤性结肠息肉病基因 (APC) 的突变使一个人易患结直肠癌。后来，随着研究的进展，人们逐渐清楚地认识到与该通路相关的基因的异常激活或突变可以驱动肿瘤发生。在这里，我们综述了关于 Wnt 信号调控及其在几种癌症亚型中的作用的最新研究进展。此外，还强调了针对 Wnt 通路的癌症治疗干预的实用性，概述了目前针对致癌过程中 Wnt 通路的方法以及与之相关的未来前景和挑战。
