Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA.
Molecules. 2019 Apr 23;24(8):1602. doi: 10.3390/molecules24081602.
Carcinogenesis is the process whereby a normal cell is transformed into a neoplastic cell. This action involves several steps starting with initiation and followed by promotion and progression. Driving these stages are oxidative stress and inflammation, which in turn encompasses a myriad of aberrant gene expressions, both within the transforming cell population and the cells within the surrounding lesion. Chemoprevention of cancer with bioreactive foods or their extracted/purified components occurs via normalizing these inappropriate gene activities. Various foods/agents have been shown to affect different gene expressions. In this review, we discuss whereby the chemoprevention activities of the red beetroot itself may disrupt carcinogenesis and the activities of the water-soluble betalains extracted from the plant.
致癌作用是指正常细胞转变为肿瘤细胞的过程。该过程涉及多个步骤，起始、促进和进展。氧化应激和炎症驱动这些阶段，进而涵盖了转化细胞群体和周围病变细胞中无数异常基因表达。通过使这些不适当的基因活性正常化，用生物活性食品或其提取/纯化成分进行癌症化学预防。已经表明，各种食品/试剂可影响不同的基因表达。在这篇综述中，我们讨论了红甜菜根本身的化学预防活性如何破坏致癌作用以及从植物中提取的水溶性甜菜素的活性。
