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从番茄花中分离的 TFH56 中抗生素合成基因簇的进化。

Evolution of Antibiotic Synthesis Gene Clusters in the TFH56, Isolated from Tomato Flower.

机构信息

Division of Applied Life Science (BK21Plus), Gyeongsang National University, Jinju 52828, Republic of Korea.

Division of Applied Life Science (BK21Plus), Gyeongsang National University, Jinju 52828, Republic of Korea

出版信息

G3 (Bethesda). 2019 Jun 5;9(6):1807-1813. doi: 10.1534/g3.119.400037.

Abstract

species are known to produce various bioactive metabolites that can prevent plant diseases. Previously, the strain TFH56 was found to inhibit the gray mold pathogen, , in tomato flower. In this study, the genome sequence of strain TFH56 was acquired using the Pacific Biosciences RS II platform. Three linear sequences (7.67 Mbp in total) were obtained. Based on average nucleotide identity, strain TFH56 was classified as , which is consistent with the presence of a linear chromosome and linear plasmids. Moreover, as with other examples of , the genome of strain TFH56 included a caryolan-1-ol synthase gene, a conprimycin synthetic gene cluster, and a lidamycin synthetic gene cluster.

摘要

已知某些物种会产生各种具有生物活性的代谢产物,可预防植物病害。先前,菌株 TFH56 被发现可抑制灰霉病病原体 , 在番茄花中。在这项研究中,使用 Pacific Biosciences RS II 平台获得了菌株 TFH56 的基因组序列。获得了三个线性序列(总计 7.67 Mbp)。根据平均核苷酸同一性,菌株 TFH56 被分类为 ,这与线性染色体和线性质粒的存在一致。此外,与其他 菌株的例子一样,菌株 TFH56 的基因组包括 Caryolan-1-ol 合酶基因、conprimycin 合成基因簇和 lidamycin 合成基因簇。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ced/6553541/870b730a639c/1807f1.jpg

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