端粒缩短作为干细胞衰老的一个标志。
Telomere shortening as a hallmark of stem cell senescence.
作者信息
Fathi Ezzatollah, Charoudeh Hojjatollah Nozad, Sanaat Zohreh, Farahzadi Raheleh
机构信息
Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Stem Cell Investig. 2019 Mar 6;6:7. doi: 10.21037/sci.2019.02.04. eCollection 2019.
Abstract
Stem cells, especially mesenchymal stem cells (MSCs)-based therapies have been greatly attentioned in regenerative medicine through multi-lineage differentiation, self-renewal properties, etc. Despite the above advantages of MSCs, the defined properties of these cells are strongly affected by aging. Thus, the use of MSCs from older donors is lower than younger one, which limits clinical applications in cell therapy. According to the theories of aging, it is determined that aging is most likely caused by telomere shortening and telomere shortening is considered hallmarks of aging. Finding out the most mechanisms of these changes will probably reveal novel therapeutic targets for prolonging human health and for ameliorating age-associated phenotypes. This review focuses on prevalent knowledge about the mechanisms of stem cell senescence by telomere shortening and the molecular mechanism details involved in it.
摘要
干细胞，尤其是基于间充质干细胞（MSCs）的疗法，因其多向分化、自我更新特性等，在再生医学中备受关注。尽管MSCs有上述优点，但其明确特性会受到衰老的强烈影响。因此，老年供体来源的MSCs使用量低于年轻供体的，这限制了其在细胞治疗中的临床应用。根据衰老理论，衰老很可能是由端粒缩短引起的，端粒缩短被认为是衰老的标志。弄清楚这些变化的大多数机制可能会揭示延长人类健康和改善与年龄相关表型的新治疗靶点。本综述重点关注端粒缩短导致干细胞衰老机制的普遍知识及其涉及的分子机制细节。
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