Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Strasse 2, 12489, Berlin, Germany.
Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA.
Angew Chem Int Ed Engl. 2019 Jul 29;58(31):10747-10751. doi: 10.1002/anie.201902217. Epub 2019 Jul 1.
Functional precision polymers based on monodisperse oligo(N-substituted acrylamide)s and oligo(2-substituted-α-hydroxy acid)s have been synthesized. The discrete sequences originate from a direct translation of side-chain functionality sequences of a peptide with well-studied properties. The peptide was previously selected to solubilize the photosensitizer meta-tetra(hydroxyphenyl)chlorin. The resulting peptidomimetic formulation additives preserve the drug solubilization and release characteristics of the parent peptide. In some cases, superior properties are obtained, reaching up to 40 % higher payloads and 27-times faster initial drug release.
基于单分散的低聚（N-取代丙烯酰胺）和低聚（2-取代-α-羟基酸）的功能精密聚合物已经被合成。这些离散序列源自具有良好研究性质的肽的侧链功能序列的直接翻译。该肽之前被选择用于溶解光敏剂 meta-四（羟基苯基）氯。所得的肽模拟制剂添加剂保留了母体肽的药物溶解和释放特性。在某些情况下，获得了更好的性能，达到高达 40%更高的载药量和 27 倍更快的初始药物释放。
