Laboratory for Organic Synthesis of Functional Systems, Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Str. 2, 12489, Berlin, Germany.
Macromol Biosci. 2020 Jan;20(1):e1900244. doi: 10.1002/mabi.201900244. Epub 2019 Sep 4.
Functional sequences of monodisperse, sequence-defined oligo(amide-urethane)s are designed based on a peptide sequence as blueprint. The translation of a discrete side-chain functionality sequence from a known peptide-based solubilizer of the photosensitizer meta-tetra(hydroxyphenyl)-chlorin, into a non-peptidic precision polymer backbone is demonstrated. The resulting peptidomimetic precision polymers retain the functions of the parent peptide sequence, showing analogues sensitivity toward single monomer mutations/exchanges and even exceeding the parent peptide equivalent by reaching up to 69% higher payload capacities and more favored release kinetics.
基于肽序列设计了单分散、序列定义的低聚（酰胺-氨基甲酸酯）的功能序列。证明了将已知基于肽的光敏剂间四（羟基苯基）-氯的增溶剂的离散侧链功能序列转化为非肽精确聚合物主链的过程。所得的肽模拟精确聚合物保留了母体肽序列的功能，对单个单体突变/交换具有类似的敏感性，甚至通过达到高达 69%更高的载药能力和更有利的释放动力学来超过母体肽当量。
