Laboratory for Organic Synthesis of Functional Systems, Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Str. 2, D-12489, Berlin, Germany.
Macromol Rapid Commun. 2017 Dec;38(24). doi: 10.1002/marc.201700632. Epub 2017 Nov 7.
Peptide sciences developed dramatically as a result of routine use of solid-phase peptide synthesis and nowadays offer a rich set of well-established strategies to design and identify functional peptide sequences for advanced applications in materials sciences. Appropriate sequences for a wide range of interesting material targets, ranging from molecules to materials surfaces and internal interfaces, can be selected via combinatorial means, and sequence specificities within the resulting peptide-target interactions can be routinely investigated. Based on this understanding, macromolecular sciences can define new polymer structures that meet required functionalities or functional sequences with fully synthetic, nonpeptidic precision polymers to endeavor toward information-based design of next-generation, purpose-adapted macromolecules.
肽科学由于固相肽合成的常规使用而得到了迅猛的发展，如今为设计和识别功能肽序列提供了丰富的成熟策略，以应用于材料科学的高级领域。通过组合手段，可以选择适用于从分子到材料表面和内部界面等各种有趣的材料目标的合适序列，并且可以常规研究所得肽-靶相互作用中的序列特异性。在此基础上，高分子科学可以用完全合成的、非肽类的精准聚合物来定义满足所需功能或功能序列的新型聚合物结构，以努力实现基于信息的下一代、适应目的的高分子的设计。
