空气污染与扁桃体周围脓肿形成风险增加的关联。
Association of Air Pollution With Increased Risk of Peritonsillar Abscess Formation.
机构信息
Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Anyang, Korea.
出版信息
JAMA Otolaryngol Head Neck Surg. 2019 Jun 1;145(6):530-535. doi: 10.1001/jamaoto.2019.0742.
IMPORTANCE
Several studies reported an association between peritonsillar abscess formation and climate conditions, including seasonal changes; however, the results were inconsistent.
OBJECTIVE
To evaluate the association between meteorological conditions and/or air pollution and peritonsillar abscess formation.
DESIGN, SETTING, AND PARTICIPANTS: In this nested case-control study, 3819 participants with peritonsillar abscesses were matched (1:4) for age, sex, income, region of residence, hypertension, diabetes, and dyslipidemia with 15 276 control participants. The Korean Health Insurance Review and Assessment Service-National Sample Cohort (HIRA-NSC) data from 2002 through 2013 were used.
EXPOSURES AND MAIN OUTCOMES AND MEASURES
The meteorological data included the mean daily temperature (°C), highest daily temperature (°C), lowest daily temperature (°C), daily temperature difference (°C), relative humidity (%), spot atmospheric pressure (hPa), sulfur dioxide ([SO2], parts per million [ppm]), nitrogen dioxide (NO2, ppm), ozone (O3, ppm), carbon monoxide (CO, ppm), and particulate matter less than 10 μg (PM10, μg/m3) for the previous 14 days, 10 days, 7 days, 5 days, or 3 days before the matched index date. These factors were measured in 94 or 273 locations hourly. The crude and adjusted odds ratios (aORs) and 95% confidence intervals (CIs) of meteorological data for peritonsillar abscess formation were analyzed using unconditional logistic regression analysis. Subgroup analyses were conducted according to age and sex.
RESULTS
The male to female ratio of study participants was 1.43 (11 260 to 7835). Because the age groups were classified using 5-year intervals, the mean age could not be defined. The mean differences of NO2 and PM10 concentrations for the 14 days between peritonsillar abscess group and control group were 1.78 ppb (95% CI, 1.47-2.09) and 1.33 μg/m3 (95% CI, 0.67-1.99), respectively. The aORs of NO2 (0.1 ppm) and PM10 (10 μg/m3) during the 14 days prior to the index date for peritonsillar abscess formation were 12.8 (95% CI, 8.4-19.5) and 1.04 (95% CI, 1.02-1.06), respectively. The other meteorological conditions did not reach statistical significance.
CONCLUSIONS AND RELEVANCE
Peritonsillar abscess formation was associated with high concentrations of NO2 and PM10.
重要性
有几项研究报告指出，扁桃体周围脓肿的形成与气候条件有关，包括季节性变化；然而，结果并不一致。
目的
评估气象条件和/或空气污染与扁桃体周围脓肿形成之间的关联。
设计、地点和参与者：在这项嵌套病例对照研究中，3819 名患有扁桃体周围脓肿的参与者与年龄、性别、收入、居住地区、高血压、糖尿病和血脂异常相匹配（1:4），共有 15276 名对照参与者。使用了 2002 年至 2013 年期间的韩国健康保险审查和评估服务-国家抽样队列（HIRA-NSC）数据。
暴露和主要结局和测量
气象数据包括前 14 天、10 天、7 天、5 天或 3 天的每日平均气温（°C）、最高日气温（°C）、最低日气温（°C）、日温差（°C）、相对湿度（%）、局部大气压力（hPa）、二氧化硫（[SO2]，百万分之几[ppm]）、二氧化氮（NO2，ppm）、臭氧（O3，ppm）、一氧化碳（CO，ppm）和小于 10μg/m3 的颗粒物（PM10，μg/m3）。这些因素每小时在 94 或 273 个地点进行测量。使用无条件逻辑回归分析分析扁桃体周围脓肿形成的气象数据的粗比值比（OR）和 95%置信区间（CI）。根据年龄和性别进行了亚组分析。
结果
研究参与者的男女比例为 1.43（11260 至 7835）。由于年龄组是按 5 年间隔分类的，所以无法确定平均年龄。扁桃体周围脓肿组和对照组 14 天内的 NO2 和 PM10 浓度差异分别为 1.78ppb（95%CI，1.47-2.09）和 1.33μg/m3（95%CI，0.67-1.99）。扁桃体周围脓肿形成前 14 天内的 NO2（0.1ppm）和 PM10（10μg/m3）的 aOR 分别为 12.8（95%CI，8.4-19.5）和 1.04（95%CI，1.02-1.06）。其他气象条件没有达到统计学意义。
结论和相关性
扁桃体周围脓肿的形成与高浓度的 NO2 和 PM10 有关。
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