Dose-duration effect of sodium cromoglycate aerosol in exercise-induced asthma.

The dose-duration effect of sodium cromoglycate given by metered dose aerosol was studied in nine patients with exercise-induced asthma. Exercise tests were carried out at 15, 135 and 255 min after placebo, sodium cromoglycate 2 mg, 10 mg and 20 mg. The protective effect and the duration of action were dose-related. The new metered dose aerosol delivering 5 mg of sodium cromoglycate per actuation allows greater flexibility in adjusting the dosage and frequency of administration for individual patients.