South East Asian Ministers of Education Organization, Regional Center for Food and Nutrition (SEAMEO RECFON) Pusat Kajian Gizi Regional, Universitas Indonesia, Jakarta 10430, Indonesia.
Township Health Department, Ministry of Health Myanmar, Hakha 03011, Chin State, Myanmar.
Nutrients. 2019 Apr 24;11(4):918. doi: 10.3390/nu11040918.
Iron absorption was impaired in the presence of sub-clinical inflammation (SCI) and might hamper the effect of iron supplementation. The purpose of the study was to identify the influence of SCI on iron supplementation. A randomized, double-blinded, placebo-controlled experimental study was conducted among anaemic adolescent schoolgirls in Ayeyarwady region, Myanmar. A total of 402 schoolgirls were recruited from six schools screened from 1269 girls who were assigned into one of four groups: Folate group (2.5 mg of folate), Vitamin A group (15,000 IU of vitamin), Iron folate group (60 mg elemental iron and folate) and Iron, and vitamin A and folate group. Supplementation was done once a week for 12 weeks. Iron, vitamin A and inflammation were measured at the baseline, middle and endline. Changes in serum ferritin and body iron were significantly higher in the IFA and IFA + vitA among those without SCI. There was interaction between vitamin A and SCI on Hb changes. Analysis of GLM repeated measure showed interactions between treatment and SCI for hemoglobin and serum transferrin receptor. Those treated with vitamin A had better outcomes when there was SCI. Inflammation accompanied a negative effect on iron supplementation and vitamin A improved efficacy of iron supplementation in the presence of SCI.
铁吸收在亚临床炎症（SCI）存在的情况下受到损害，可能会影响铁补充剂的效果。本研究旨在确定 SCI 对铁补充的影响。在缅甸伊洛瓦底地区，对患有贫血的青少年女学生进行了一项随机、双盲、安慰剂对照的实验研究。从 1269 名女生中筛选出 6 所学校的 402 名女生被分配到以下 4 组中的一组：叶酸组（2.5 毫克叶酸）、维生素 A 组（15000IU 维生素 A）、铁叶酸组（60 毫克元素铁和叶酸）和铁、维生素 A 和叶酸组。每周补充一次，持续 12 周。在基线、中间和终线测量铁、维生素 A 和炎症。在没有 SCI 的情况下，IFA 和 IFA+vitA 组的血清铁蛋白和体内铁的变化明显更高。维生素 A 和 SCI 对 Hb 变化有交互作用。GLM 重复测量分析显示，治疗和 SCI 之间存在血红蛋白和血清转铁蛋白受体的相互作用。当存在 SCI 时，维生素 A 的治疗效果更好。炎症伴随着铁补充的负面影响，而维生素 A 改善了 SCI 存在时铁补充的效果。
