Abrahão Camila Aparecida, Bomfim Emiliana, Lopes-Júnior Luís Carlos, Pereira-da-Silva Gabriela
1 University of Franca at Franca College of Medicine-UNIFRAN, Franca, São Paulo, Brazil.
2 University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
J Evid Based Integr Med. 2019 Jan-Dec;24:2515690X19838897. doi: 10.1177/2515690X19838897.
The stress associated with cancer development leads to disturbances in the hypothalamic-pituitary-adrenal axis and suppresses important facets of the immune response. The use of complementary therapies in the treatment of women with breast cancer has demonstrated therapeutic benefits that entail improvements in the patients' quality of life. The objective of this article is to present evidence on the use of complementary therapies as a stress reduction strategy and on its stimulating effects on the immune system of women with breast cancer. This is a reflexive updating article that will support the health professionals' understanding on the use of complementary therapies in breast cancer care. The use of complementary therapies in the treatment of women with breast cancer has significantly improved these subjects' stress, depression, fatigue, anxiety, and consequently, their quality of life, as well as their immune response, which is mainly illustrated by the increased number and cytotoxic activity of natural killer cells. Clinicians, health professionals and patients need to be cautious about using complementary therapies and fully understand the real benefits and risks associated with each therapy. Little or no supporting evidence is available to clarify the effects on the immune system of women with breast cancer, and the consequent therapeutic benefits obtained through the use of these practices.
与癌症发展相关的压力会导致下丘脑 - 垂体 - 肾上腺轴紊乱，并抑制免疫反应的重要方面。在乳腺癌女性患者的治疗中使用补充疗法已显示出治疗益处，包括改善患者的生活质量。本文的目的是提供关于使用补充疗法作为减轻压力策略及其对乳腺癌女性免疫系统刺激作用的证据。这是一篇反思性更新文章，将有助于健康专业人员理解在乳腺癌护理中使用补充疗法的情况。在乳腺癌女性患者的治疗中使用补充疗法已显著改善了这些患者的压力、抑郁、疲劳、焦虑状况，从而改善了她们的生活质量以及免疫反应，这主要表现为自然杀伤细胞数量增加和细胞毒性活性增强。临床医生、健康专业人员和患者在使用补充疗法时需要谨慎，并充分了解每种疗法的实际益处和风险。目前几乎没有支持性证据来阐明这些疗法对乳腺癌女性免疫系统的影响以及由此获得的治疗益处。
