Pulverer G, Peters G
Infection. 1986;14 Suppl 4:S245-7. doi: 10.1007/BF01661283.
The in vitro activity of ofloxacin was tested against freshly isolated strains, from clinical material, of Pseudomonas aeruginosa, Staphylococcus aureus, and coagulase-negative staphylococci, including strains that were resistant to methicillin and/or novobiocin. 97% of the Pseudomonas strains were inhibited by ofloxacin concentrations in the range of 0.78 to 6.25 mg/l, with 55% of the strains being inhibited by concentrations up to 1.56 mg/l. All of the staphylococci strains, including those resistant to novobiocin and/or methicillin, were sensitive to ofloxacin in the range 0.19 to 1.56 mg/l. The influence of ofloxacin on cellular and humoral host immunity was evaluated both in vivo and in vitro. The influence of the compound on phagocytic activity of human polymorphonuclear leucocytes was evaluated by luminol-enhanced chemiluminescence. Ofloxacin did not influence cell-mediated immunity. It had no effect on chemotaxis. The use of sub-inhibitory concentrations of ofloxacin enhanced the phagocytic kill rate.
对从临床材料中分离出的铜绿假单胞菌、金黄色葡萄球菌和凝固酶阴性葡萄球菌的新鲜菌株进行了氧氟沙星的体外活性测试，这些菌株包括对甲氧西林和/或新生霉素耐药的菌株。97%的假单胞菌菌株被浓度在0.78至6.25mg/l范围内的氧氟沙星抑制，55%的菌株被浓度高达1.56mg/l的氧氟沙星抑制。所有葡萄球菌菌株，包括对新生霉素和/或甲氧西林耐药的菌株，在0.19至1.56mg/l范围内对氧氟沙星敏感。在体内和体外评估了氧氟沙星对宿主细胞免疫和体液免疫的影响。通过鲁米诺增强化学发光评估该化合物对人多形核白细胞吞噬活性的影响。氧氟沙星不影响细胞介导的免疫。它对趋化性没有影响。使用亚抑制浓度的氧氟沙星可提高吞噬杀菌率。
