Götz F, Gimes L, Hübler J, Temes G, Frang D
Int Urol Nephrol. 1986;18(4):363-8. doi: 10.1007/BF02084105.
Induced precipitation of Ca-oxalate crystals and the possibility of its prevention were studied in dogs. In the first phase of the experiments precipitation of Ca-oxalate crystals in canine renal tubules was induced by intraperitoneal administration of Na-glyoxylate. Preventive medication (lipoic acid, vitamin B1, Milurit), applied in the second phase, resulted in a significant depression of induced precipitation. The successful experiments serve as a basis for clinical research aimed at a preventive medication of recurrent Ca-oxalate stone formation.
在犬类动物中研究了草酸钙晶体的诱导沉淀及其预防的可能性。在实验的第一阶段，通过腹腔注射乙醛酸钠诱导犬肾小管中草酸钙晶体的沉淀。在第二阶段应用的预防性药物（硫辛酸、维生素B1、米鲁利特）导致诱导沉淀显著减少。这些成功的实验为旨在预防复发性草酸钙结石形成的临床研究奠定了基础。
