Jayanthi S, Saravanan N, Varalakshmi P
Department of Medical Biochemistry, Dr A.L. Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, India.
Pharmacol Res. 1994 Oct-Nov;30(3):281-8. doi: 10.1016/1043-6618(94)80110-x.
Glyoxylic lithiasis by acute intoxication with sodium glyoxylate, significantly raised the levels of renal tissue calcium and oxalate which has been reflected simultaneously in their urinary levels. Administration of DL alpha-lipoic acid lowered the oxalate levels in the kidney and urine. Sodium glyoxylate administration resulted in enhanced liver glycollate oxidase activity, the major enzyme in endogenous oxalate synthesis. DL alpha-lipoic acid decreased glycollate oxidase activity but did not have any effect on lactate dehydrogenase. The possibility of regulating oxalate metabolism in glyoxylic lithiasis with the use of DL alpha-lipoic acid, by way of inhibiting liver glycollate oxidase, looks attractive.
乙醛酸锂盐因乙醛酸钠急性中毒而形成结石，显著提高了肾组织钙和草酸盐的水平，这同时也反映在尿液水平上。给予DL-α硫辛酸可降低肾脏和尿液中的草酸盐水平。给予乙醛酸钠会导致肝脏乙醇酸氧化酶活性增强，这是内源性草酸盐合成中的主要酶。DL-α硫辛酸降低了乙醇酸氧化酶活性，但对乳酸脱氢酶没有任何影响。通过抑制肝脏乙醇酸氧化酶，利用DL-α硫辛酸调节乙醛酸结石症中草酸盐代谢的可能性看起来很有吸引力。
