Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.
MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary.
Transl Psychiatry. 2016 May 3;6(5):e798. doi: 10.1038/tp.2016.57.
Several studies indicate that 5-HTTLPR mediates the effect of childhood adversity in the development of depression, while results are contradictory for recent negative life events. For childhood adversity the interaction with genotype is strongest for sexual abuse, but not for other types of childhood maltreatment; however, possible interactions with specific recent life events have not been investigated separately. The aim of our study was to investigate the effect of four distinct types of recent life events in the development of depressive symptoms in a large community sample. Interaction between different types of recent life events measured by the List of Threatening Experiences and the 5-HTTLPR genotype on current depression measured by the depression subscale and additional items of the Brief Symptom Inventory was investigated in 2588 subjects in Manchester and Budapest. Only a nominal interaction was found between life events overall and 5-HTTLPR on depression, which failed to survive correction for multiple testing. However, subcategorising life events into four categories showed a robust interaction between financial difficulties and the 5-HTTLPR genotype, and a weaker interaction in the case of illness/injury. No interaction effect for the other two life event categories was present. We investigated a general non-representative sample in a cross-sectional approach. Depressive symptoms and life event evaluations were self-reported. The 5-HTTLPR polymorphism showed a differential interaction pattern with different types of recent life events, with the strongest interaction effects of financial difficulties on depressive symptoms. This specificity of interaction with only particular types of life events may help to explain previous contradictory findings.
几项研究表明，5-HTTLPR 介导了童年逆境对抑郁症发展的影响，而最近的负面生活事件的结果则存在矛盾。对于童年逆境，与基因型的相互作用在性虐待方面最强，但在其他类型的儿童虐待方面则不然；然而，尚未分别研究与特定的近期生活事件的可能相互作用。我们的研究目的是在一个大型社区样本中研究四种不同类型的近期生活事件对抑郁症状发展的影响。在曼彻斯特和布达佩斯的 2588 名受试者中，通过威胁体验清单和Brief Symptom Inventory 的抑郁子量表和其他项目测量的最近生活事件，以及 5-HTTLPR 基因型，调查了不同类型的最近生活事件之间的相互作用。仅发现生活事件总体与 5-HTTLPR 之间与抑郁相关的名义相互作用，且在进行多次检验校正后无法生存。然而，将生活事件细分为四类后，发现经济困难与 5-HTTLPR 基因型之间存在稳健的相互作用，而在疾病/伤害的情况下则存在较弱的相互作用。其他两种生活事件类别的相互作用效应不存在。我们采用横断面方法研究了一般非代表性样本。抑郁症状和生活事件评估是自我报告的。5-HTTLPR 多态性显示出与不同类型的近期生活事件的不同相互作用模式，经济困难与抑郁症状的相互作用最强。这种与特定类型的生活事件的相互作用的特异性可能有助于解释以前相互矛盾的发现。
