Department of Psychology, University of Miami, Coral Gables, FL, USA.
Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2020 Mar;27(2):254-269. doi: 10.1080/13825585.2019.1606889. Epub 2019 Apr 26.
This study examined the association between self-reported fatigue and neuropsychological performance in 167 middle-aged and older (age range: 50-91 years) adults without dementia. Participants completed the Fatigue Symptom Inventory, a comprehensive neuropsychological evaluation, and frailty assessment. Higher levels of fatigue were significantly associated with poorer attention/information processing, executive functioning, and psychomotor speed, even after controlling for depression, sleep quality, physical weakness, and other covariates. Participants endorsing moderate-severe fatigue faced higher odds ( 6.6, 95% CI = 1.1, 39.1) of exhibiting clinical attention/information processing impairments than those without. Moderation analyses showed that fatigue was related to select cognitive deficits among those reporting mean or lower levels of activity, but not high levels. These findings highlight fatigue as an important clinical marker of select cognitive deficits in non-demented older adults that is distinct from the common confounding conditions examined in this study. High levels of physical activity may buffer this relationship.
本研究调查了 167 名中年及以上（年龄范围：50-91 岁）无痴呆成年人中自我报告的疲劳与神经心理学表现之间的关系。参与者完成了疲劳症状量表、全面的神经心理学评估和虚弱评估。即使在控制了抑郁、睡眠质量、身体虚弱和其他协变量后，更高水平的疲劳与注意力/信息处理、执行功能和精神运动速度较差显著相关。报告中等到严重疲劳的参与者表现出临床注意力/信息处理障碍的几率更高（6.6，95%CI=1.1，39.1）比没有报告的参与者。调节分析表明，在报告中等或较低水平活动的参与者中，疲劳与某些认知缺陷有关，但与高水平活动无关。这些发现强调了疲劳作为非痴呆老年成年人中某些认知缺陷的重要临床标志物，与本研究中检查的常见混杂条件不同。高水平的身体活动可能会缓冲这种关系。
