Suzukamo Chika, Ochiai Ryuji, Mitsui Yuki, Osaki Noriko, Ono Takahiro
Biological Science Research, Kao Corporation, Tokyo 131-8501, Japan.
Health & Wellness Products Research, Kao Corporation, Tokyo 131-8501, Japan.
Brain Sci. 2022 Mar 11;12(3):370. doi: 10.3390/brainsci12030370.
Chlorogenic acid (CGA), a polyphenolic compound found in various plants, has been reported to improve cognitive function. However, it remains unclear how long it takes for CGAs to exert their effects. Here, we evaluated the short-term effects of CGAs on cognitive function. We assessed the effects of 2-week CGA intake on cognitive function. The study was carried out as a randomized, double-blind, placebo-controlled, crossover trial. Twenty-six healthy Japanese participants (50-65 years of age) were randomly assigned to either the active beverage (CGAs: 270 mg) or the placebo beverage group daily for 2 weeks. After a 2-week washout period, the participants consumed the other beverages. We assessed cognitive function at baseline and following the first treatment period using the Japanese version of CNS Vital Signs. CGAs significantly improved the scores for psychomotor speed, motor speed, and right and left finger tapping compared to placebo. In addition, processing speed scores improved significantly from baseline only after CGA intake. In conclusion, CGAs were confirmed to improve cognitive function over a short period of two weeks.
绿原酸（CGA）是一种存在于多种植物中的多酚类化合物，据报道它能改善认知功能。然而，CGA发挥作用需要多长时间仍不清楚。在此，我们评估了CGA对认知功能的短期影响。我们评估了连续2周摄入CGA对认知功能的影响。该研究作为一项随机、双盲、安慰剂对照的交叉试验进行。26名健康的日本参与者（年龄在50 - 65岁之间）被随机分配到活性饮料组（CGA：270毫克）或安慰剂饮料组，每天饮用，持续2周。经过2周的洗脱期后，参与者饮用另一种饮料。我们在基线时以及第一个治疗期结束后使用日语版的CNS生命体征评估认知功能。与安慰剂相比，CGA显著提高了心理运动速度、运动速度以及左右手指敲击的得分。此外，仅在摄入CGA后，处理速度得分从基线有显著提高。总之，证实CGA在两周的短时间内就能改善认知功能。
