Firnau G, Sood S, Chirakal R, Nahmias C, Garnett E S
J Neurochem. 1987 Apr;48(4):1077-82. doi: 10.1111/j.1471-4159.1987.tb05629.x.
The tracers 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine (6-[18F]fluoro-L-DOPA) and L-[14C]DOPA were injected simultaneously into rhesus monkeys, and the time course of their metabolites was measured in the striatum and in the occipital and frontal cortices. In the striatum, 6-[18F]fluoro-L-DOPA was metabolized to 6-[18F]fluorodopamine, 3,4-dihydroxy-6-[18F]fluorophenylacetic acid, and 6-[18F]fluorohomovanillic acid. The metabolite pattern was qualitatively similar to that of L-[14C]DOPA. 6-[18F]Fluorodopamine was synthesized faster than [14C]dopamine. In the frontal cortex, the major metabolite was also 6-[18F]fluorodopamine or [14C]dopamine. In the occipital cortex, the major metabolite was 3-O-methyl-6-[18F]fluoro-L-DOPA. On the basis of these data, the images obtained with 6-[18F]fluoro-L-DOPA and positron emission tomography in humans can now be interpreted in neurochemical terms.
将示踪剂6-[¹⁸F]氟-L-3,4-二羟基苯丙氨酸（6-[¹⁸F]氟-L-DOPA）和L-[¹⁴C]DOPA同时注射到恒河猴体内，并在纹状体、枕叶和额叶皮质中测量它们代谢物的时间进程。在纹状体中，6-[¹⁸F]氟-L-DOPA代谢为6-[¹⁸F]氟多巴胺、3,4-二羟基-6-[¹⁸F]氟苯乙酸和6-[¹⁸F]氟高香草酸。代谢物模式在质量上与L-[¹⁴C]DOPA相似。6-[¹⁸F]氟多巴胺的合成速度比[¹⁴C]多巴胺快。在额叶皮质中，主要代谢物也是6-[¹⁸F]氟多巴胺或[¹⁴C]多巴胺。在枕叶皮质中，主要代谢物是3-O-甲基-6-[¹⁸F]氟-L-DOPA。基于这些数据，现在可以从神经化学角度解释用6-[¹⁸F]氟-L-DOPA和正电子发射断层扫描在人体获得的图像。
