Kuznetsova T A, Ivanushko L A, Persiyanova E V, Ermakova S P, Besednova N N
G. P. Somov Research Institute of Epidemiology and Microbiology, Far-Eastern Division of the Russian Academy of Sciences, Vladivostok, Russia.
G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Division of the Russian Academy of Sciences, Vladivostok, Russia.
Bull Exp Biol Med. 2019 Apr;166(6):766-769. doi: 10.1007/s10517-019-04436-w. Epub 2019 Apr 26.
The effect of sulfated polysaccharide from brown alga Fucus evanescens (fucoidan) administered via different routes (peroral and parenteral) on the dynamic of some lipid metabolism parameters and markers of systemic inflammation in mice with experimental dyslipidemia induced by prolonged administration of poloxamer P-407. It was found that fucoidan corrected the main parameters of lipid metabolism, reduced the level of endothelial dysfunction marker endothelin-1 and proinflammatory cytokines TNFα, IFNγ in blood serum in animals with experimental dyslipidemia. These findings open prospects for using fucoidan in the complex treatment of metabolic disorders and atherosclerotic inflammation.
通过不同途径（口服和肠胃外）给予褐藻岩藻（岩藻聚糖硫酸酯）对长期给予泊洛沙姆P - 407诱导的实验性血脂异常小鼠的某些脂质代谢参数动态及全身炎症标志物的影响。研究发现，岩藻聚糖硫酸酯可纠正脂质代谢的主要参数，降低实验性血脂异常动物血清中内皮功能障碍标志物内皮素 - 1以及促炎细胞因子TNFα、IFNγ的水平。这些发现为岩藻聚糖硫酸酯用于代谢紊乱和动脉粥样硬化炎症的综合治疗开辟了前景。
