Department of Chemical Sciences, University of Naples Federico II, Napoli, Italy.
Department of Chemical Sciences, University of Naples Federico II, Napoli, Italy.
Nanomedicine. 2019 Aug;20:101997. doi: 10.1016/j.nano.2019.04.001. Epub 2019 Apr 25.
The encapsulation of anticancer metal-based drugs within a protein nanocage represents a valuable strategy to improve the efficacy and selectivity of these compounds towards cancer cells. The preparation, characterization of the in vitro cytotoxicity and X-ray structures of several ferritin-metallodrug nanocomposites (mainly containing platinum-, ruthenium- and gold-based anticancer agents) are here reviewed. The molecular mechanisms of action of these Ft-metallodrug adducts are discussed and future directions in the field are outlined.
将抗癌金属基药物封装在蛋白质纳米笼内是一种提高这些化合物对癌细胞的疗效和选择性的有价值的策略。本文综述了几种铁蛋白-金属药物纳米复合物（主要含有铂、钌和金基抗癌剂）的制备、体外细胞毒性表征和 X 射线结构。讨论了这些 Ft-金属药物加合物的作用机制，并概述了该领域的未来发展方向。
