Department of Biochemistry, University of Nebraska, Lincoln, NE 68588, United States of America.
Department of Biochemistry, University of Nebraska, Lincoln, NE 68588, United States of America; Nebraska Redox Biology Center, University of Nebraska, Lincoln, NE 68588, United States of America; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, United States of America.
Mitochondrion. 2019 Nov;49:289-304. doi: 10.1016/j.mito.2019.04.008. Epub 2019 Apr 25.
Spatiotemporal changes in the abundance, shape, and cellular localization of the mitochondrial network, also known as mitochondrial dynamics, are now widely recognized to play a key role in mitochondrial and cellular physiology as well as disease states. This process involves coordinated remodeling of the outer and inner mitochondrial membranes by conserved dynamin-like guanosine triphosphatases and their partner molecules in response to various physiological and stress stimuli. Although the core machineries that mediate fusion and partitioning of the mitochondrial network have been extensively characterized, many aspects of their function and regulation are incompletely understood and only beginning to emerge. In the present review we briefly summarize current knowledge about how the key mitochondrial dynamics-mediating factors are regulated via selective proteolysis by mitochondrial and cellular proteolytic machineries.
线粒体网络的丰度、形态和细胞定位的时空变化，也称为线粒体动力学，现在被广泛认为在线粒体和细胞生理学以及疾病状态中发挥关键作用。这个过程涉及到保守的类似于 dynamin 的鸟苷三磷酸酶及其伴侣分子通过对外膜和内膜的协调重塑，以响应各种生理和应激刺激。尽管介导线粒体网络融合和分裂的核心机械已经得到广泛的描述，但它们的许多功能和调节方面仍不完全清楚，目前才刚刚开始出现。在本综述中，我们简要总结了目前关于关键线粒体动力学调节因子如何通过线粒体和细胞蛋白水解机制的选择性蛋白水解来调节的知识。
