Faculty of Nutrition, Federal University of Goiás, Goiânia, Goiás, Brazil.
Chemistry Institute, Federal University of Goiás, Goiânia, Goiás, Brazil.
Nutrition. 2019 Sep;65:68-73. doi: 10.1016/j.nut.2019.03.004. Epub 2019 Mar 16.
Beet leaves and stalks are rich in polyphenols; however, their effect on risk factors for cardiovascular disease in humans, to our knowledge, has not yet been investigated. The aim of this study was to analyze the acute effect of beet leaves and stalk juice, containing different concentrations of polyphenols, on lipemia, glycemic control, nitric oxide concentration, and blood pressure in patients with dyslipidemia after a high-fat meal.
In a randomized double-blind, placebo-controlled, crossover pilot study, patients 20 to 59 y of age with dyslipidemia were fed a single high-fat meal supplemented with either a placebo or one of two organic beet leaves and stalk juices rich in polyphenols (32 or 77.5 mg EAG/100 mL) with a 1-wk washout. Thus, each group was composed of 13 patients. Blood samples were obtained at fasting and 30, 60, 120, and 180 min after intervention. Total cholesterol, high-density lipoprotein, triacylglycerols, glucose, insulin, nitrite and nitrate, and blood pressure were assessed at each time period. The high-fat meal increased triacylglycerol levels after 120 (P < 0.001) and 180 min (P < 0.001) and reduced high-density lipoprotein cholesterol after 60 min (P < 0.05). This reduction was attenuated in both groups that received BLS juices after 120 min (P = 0.005). A reduction in diastolic blood pressure within groups that received BLS juice was also observed.
There was no significant difference between groups for other biomarkers.
The beet leaves and stalk juice attenuated the reduction of high-density lipoprotein cholesterol induced by a high-fat meal.
甜菜叶和茎富含多酚；然而，据我们所知，它们对人类心血管疾病风险因素的影响尚未得到研究。本研究的目的是分析富含多酚的甜菜叶和茎汁对高脂餐后血脂异常患者脂血症、血糖控制、一氧化氮浓度和血压的急性影响。
在一项随机、双盲、安慰剂对照、交叉先导研究中，年龄在 20 至 59 岁的血脂异常患者食用高脂肪餐，并补充安慰剂或两种富含多酚的有机甜菜叶和茎汁（32 或 77.5mg EAG/100mL），洗脱期为 1 周。因此，每组由 13 名患者组成。在干预后 30、60、120 和 180 分钟时采集空腹和血液样本。在每个时间点评估总胆固醇、高密度脂蛋白、三酰甘油、葡萄糖、胰岛素、亚硝酸盐和硝酸盐以及血压。高脂肪餐在 120（P<0.001）和 180 分钟（P<0.001）后增加了三酰甘油水平，并在 60 分钟后降低了高密度脂蛋白胆固醇（P<0.05）。在接受 BLS 汁的两组中，这种降低在 120 分钟后减弱（P=0.005）。接受 BLS 汁的两组的舒张压也有降低。
各组之间其他生物标志物无显著差异。
甜菜叶和茎汁减轻了高脂肪餐引起的高密度脂蛋白胆固醇降低。
