Hirayama M, Yokochi T, Shimokata K, Iida M, Fujiki N
Neurosci Lett. 1986 Dec 23;72(3):369-74. doi: 10.1016/0304-3940(86)90543-4.
gamma-Interferon (IFN-gamma) is known to induce expression of major histocompatibility complex (MHC) class II antigens on murine astrocytes and MHC class I antigens on murine oligodendrocytes. We studied whether the human IFN-gamma could induce the expression of Human Leukocyte Antigen (HLA)-A, B, C and -DR antigens on cultured human glia from autopsied brain white matter tissue. HLA-A, B, C antigens were induced on both human astrocytes and oligodendrocytes, whereas HLA-DR antigens were induced only on some astrocytes. From these results, it is suggested that IFN-gamma affects the expression of MHC class I and class II antigens on astrocytes and oligodendrocytes derived from human brain. The relationship between the induction of MHC class I and class II antigens by IFN-gamma and the pathogenesis of multiple sclerosis is discussed.
已知γ干扰素（IFN-γ）可诱导小鼠星形胶质细胞上主要组织相容性复合体（MHC）Ⅱ类抗原以及小鼠少突胶质细胞上MHCⅠ类抗原的表达。我们研究了人IFN-γ是否能诱导源自尸检脑白质组织的培养人神经胶质细胞上人类白细胞抗原（HLA）-A、B、C和-DR抗原的表达。HLA-A、B、C抗原在人星形胶质细胞和少突胶质细胞上均被诱导表达，而HLA-DR抗原仅在部分星形胶质细胞上被诱导表达。从这些结果推测，IFN-γ影响源自人脑的星形胶质细胞和少突胶质细胞上MHCⅠ类和Ⅱ类抗原的表达。本文还讨论了IFN-γ诱导MHCⅠ类和Ⅱ类抗原表达与多发性硬化症发病机制之间的关系。
