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1
E-rosette-forming cells at 29 degrees C: an assay for the evaluation of the immune status of cancer patients.29摄氏度下的E玫瑰花结形成细胞：一种评估癌症患者免疫状态的检测方法。
Br J Cancer. 1978 Nov;38(5):606-11. doi: 10.1038/bjc.1978.256.
2
Mixed rosette assay for the detection of T mu and T gamma lymphocytes.用于检测Tμ和Tγ淋巴细胞的混合玫瑰花结试验。
J Immunol Methods. 1980;36(3-4):197-209. doi: 10.1016/0022-1759(80)90125-8.
3
Low affinity E-rosette formation by the human K cell.人K细胞形成低亲和力E花环。
J Immunol. 1978 Jan;120(1):90-5.
4
Human autologous rosettes. II. Prognostic significance of variations in autologous rosette-forming cells in the peripheral blood of cancer patients.人自体玫瑰花结。II. 癌症患者外周血中自体玫瑰花结形成细胞变化的预后意义。
J Natl Cancer Inst. 1979 Sep;63(3):593-7. doi: 10.1093/jnci/63.3.593.
5
Thymus-derived rosette-forming cells in various human disease states: cancer, lymphoma, bacterial and viral infections, and other diseases.处于各种人类疾病状态下的胸腺来源的玫瑰花结形成细胞：癌症、淋巴瘤、细菌和病毒感染以及其他疾病。
J Clin Invest. 1973 May;52(5):1026-32. doi: 10.1172/JCI107267.
6
Increased stability of E-rosettes and restricted capping of sheep erythrocytes by lymphocytes of aged humans.老年人淋巴细胞对E玫瑰花结稳定性的增强及对绵羊红细胞帽形成的限制。
Mech Ageing Dev. 1982 Jan;18(1):47-52. doi: 10.1016/0047-6374(82)90028-8.
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Decreased autologous rosette-forming T lymphocytes in alcoholic cirrhosis: absence of correlation with other T cell markers and with delayed cutaneous hypersensitivity.酒精性肝硬化患者中自体玫瑰花结形成T淋巴细胞减少：与其他T细胞标志物及迟发型皮肤超敏反应无相关性。
Int Arch Allergy Appl Immunol. 1980;61(3):337-43. doi: 10.1159/000232456.
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Increased proportion of active sheep erythrocyte rosette-forming lymphocytes and plasma rosette enhancement in sarcoidosis.结节病中活性绵羊红细胞玫瑰花结形成淋巴细胞比例增加及血浆玫瑰花结增强。
Am Rev Respir Dis. 1979 Mar;119(3):383-9. doi: 10.1164/arrd.1979.119.3.383.
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Active T-rosette-forming cells in the peripheral blood of cancer patients.癌症患者外周血中的活性T淋巴细胞玫瑰花结形成细胞。
Cancer Res. 1976 Sep;36(9 pt.1):3274-8.
10
The effect of varying SRBC/lymphocyte ratio on T cell rosette formation.不同SRBC/淋巴细胞比例对T细胞玫瑰花结形成的影响。
Arch Immunol Ther Exp (Warsz). 1978;26(1-6):347-9.

引用本文的文献

1
Lymphoid cells in lymph nodes and peripheral blood of patients with squamous cell carcinoma of the head and neck.头颈部鳞状细胞癌患者淋巴结和外周血中的淋巴细胞
J Cancer Res Clin Oncol. 1982;102(3):277-87. doi: 10.1007/BF00411348.

本文引用的文献

1
Crohn's disease and carcinoma of colon.克罗恩病与结肠癌
Br Med J. 1968 May 25;2(5603):466-8. doi: 10.1136/bmj.2.5603.466.
2
Crohn's disease and cancer.克罗恩病与癌症。
N Engl J Med. 1973 Nov 22;289(21):1099-103. doi: 10.1056/NEJM197311222892101.
3
Cell-mediated immune status of breast cancer patients: evaluation by skin tests, lymphocyte stimulation, and counts of rosette-forming cells.乳腺癌患者的细胞介导免疫状态：通过皮肤试验、淋巴细胞刺激及玫瑰花结形成细胞计数进行评估。
J Natl Cancer Inst. 1974 Sep;53(3):641-5. doi: 10.1093/jnci/53.3.641.
4
T lymphocytes in bladder and prostatic cancer patients.膀胱癌和前列腺癌患者的T淋巴细胞。
J Urol. 1974 Sep;112(3):378-82. doi: 10.1016/s0022-5347(17)59735-9.
5
Thymus-derived rosette-forming cells in various human disease states: cancer, lymphoma, bacterial and viral infections, and other diseases.处于各种人类疾病状态下的胸腺来源的玫瑰花结形成细胞：癌症、淋巴瘤、细菌和病毒感染以及其他疾病。
J Clin Invest. 1973 May;52(5):1026-32. doi: 10.1172/JCI107267.
6
New formulation of digoxin.地高辛的新剂型
Lancet. 1972 Oct 28;2(7783):922-3.
7
Performance of a rosette assay between lymphocytes and sheep erythrocytes at elevated temperatures to study patients with cancer and other diseases.在高温条件下进行淋巴细胞与绵羊红细胞的玫瑰花结试验，以研究癌症患者和其他疾病患者。
Clin Immunol Immunopathol. 1976 Jan;5(1):60-6. doi: 10.1016/0090-1229(76)90149-5.
8
The significance of varying SRBC/lymphocyte ratio in T cell rosette formation.T细胞玫瑰花结形成中不同SRBC/淋巴细胞比值的意义。
J Immunol. 1976 May;116(5):1397-9.
9
A modified assay for the detection of human adult active rosette forming lymphocytes.一种用于检测人类成年活性玫瑰花结形成淋巴细胞的改良检测方法。
J Immunol Methods. 1975;8(1-2):175-84. doi: 10.1016/0022-1759(75)90094-0.
10
Demonstration of nonspecific suppressor cells in the peripheral lymphocytes of cancer patients.癌症患者外周淋巴细胞中非特异性抑制细胞的证明。
Cancer Res. 1978 Feb;38(2):288-96.

29摄氏度下的E玫瑰花结形成细胞：一种评估癌症患者免疫状态的检测方法。

E-rosette-forming cells at 29 degrees C: an assay for the evaluation of the immune status of cancer patients.

作者信息

Quan P C, Burtin P

出版信息

Br J Cancer. 1978 Nov;38(5):606-11. doi: 10.1038/bjc.1978.256.

DOI:10.1038/bjc.1978.256
PMID:310311
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2009783/
Abstract

High-affinity rosette-forming T-cell assays were performed by incubation of peripheral-blood mononuclear cells with sheep erythrocytes (E) at 29 degrees C. As compared with normal controls, the levels of high-affinity rosette-forming cells (RFC) were much more frequently depressed in cancer patients than were the total E-RFC incubated at 4 degrees C. Only 2/83 normal controls had less than 38% 29 degrees C E-RFC (mean 48 +/- 5), whilst 78/89 cancer patients were below this level. The few postoperative patients tested exhibited a normal range of 29 degrees C E-RFC. The 29 degrees C E-rosette assay gives reproducible counts of a T-cell subset, and is a sensitive assay for evaluating the immune status of cancer patients.

摘要

高亲和力玫瑰花结形成T细胞检测是通过在29摄氏度下将外周血单个核细胞与绵羊红细胞（E）孵育来进行的。与正常对照组相比，癌症患者中高亲和力玫瑰花结形成细胞（RFC）的水平比在4摄氏度下孵育的总E-RFC更频繁地降低。只有2/83的正常对照者29摄氏度E-RFC低于38%（平均48±5），而89例癌症患者中有78例低于此水平。少数接受检测的术后患者29摄氏度E-RFC处于正常范围。29摄氏度E玫瑰花结检测可对T细胞亚群进行可重复计数，是评估癌症患者免疫状态的一种敏感检测方法。