Qin Xingping, Cheng Jing, Zhong Yi, Mahgoub Omer Kamal, Akter Farhana, Fan Yanqin, Aldughaim Mohammed, Xie Qiurong, Qin Lingxia, Gu Lijuan, Jian Zhihong, Xiong Xiaoxing, Liu Renzhong
Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China.
Department of Neurosurgery, Harvard Medical School, Boston, MA, United States.
Front Mol Neurosci. 2019 Apr 11;12:88. doi: 10.3389/fnmol.2019.00088. eCollection 2019.
Hypoxic ischemic encephalopathy (HIE) is a type of neonatal brain injury, which occurs due to lack of supply and oxygen deprivation to the brain. It is associated with a high morbidity and mortality rate. There are several therapeutic strategies that can be used to improve outcomes in patients with HIE. These include cell therapies such as marrow mesenchymal stem cells (MSCs) and umbilical cord blood stem cells (UCBCs), which are being incorporated into the new protocols for the prevention of ischemic brain damage. The focus of this review is to discuss the mechanism of oxidative stress in HIE and summarize the current available treatments for HIE. We hope that a better understanding of the relationship between oxidative stress and HIE will provide new insights on the potential therapy of this devastating condition.
缺氧缺血性脑病（HIE）是一种新生儿脑损伤，由于大脑供血不足和缺氧而发生。它与高发病率和死亡率相关。有几种治疗策略可用于改善HIE患者的预后。这些包括细胞疗法，如骨髓间充质干细胞（MSCs）和脐带血干细胞（UCBCs），它们正被纳入预防缺血性脑损伤的新方案中。本综述的重点是讨论HIE中氧化应激的机制，并总结目前可用的HIE治疗方法。我们希望对氧化应激与HIE之间关系的更好理解将为这种毁灭性疾病的潜在治疗提供新的见解。
