Weisz George M
School of Humanities, University of New England, Armidale, and University of New South Wales, Sydney, NSW, Australia.
Isr Med Assoc J. 2019 Apr;21(4):237-240.
Throughout history, studies on episodes of famine have led to the discovery of metabolic abnormalities and hormonal aberrations as well as an increased incidence of cancer and mental health conditions. Starvation during early life is thought to nfluence the programming of childhood and adult bone metabolism, which may result in poor bone health in later life. This observational case series includes a small group (with no control group) of famine-exposed Holocaust survivors and their descendants. We proposed an investigational mechanism to determine any association between starvation and osteoporosis, both in the individual survivors and in their descendants.
纵观历史，对饥荒时期的研究已促成了对代谢异常、激素失调以及癌症和心理健康问题发病率上升的发现。早年经历饥饿被认为会影响儿童期和成年期骨骼代谢的编程，这可能导致晚年骨骼健康不佳。这个观察性病例系列纳入了一小群（无对照组）经历过饥荒的大屠杀幸存者及其后代。我们提出了一种研究机制，以确定饥饿与骨质疏松症之间在个体幸存者及其后代中的任何关联。
