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气杆菌素合成蛋白作为高毒力菌株中的抗毒力靶点

Aerobactin Synthesis Proteins as Antivirulence Targets in Hypervirulent .

作者信息

Russo Thomas A, Gulick Andrew M

机构信息

The Veterans Administration Western New York Healthcare System , 3495 Bailey Avenue , Buffalo , New York 14215 , United States.

出版信息

ACS Infect Dis. 2019 Jul 12;5(7):1052-1054. doi: 10.1021/acsinfecdis.9b00117. Epub 2019 Apr 29.

Abstract

Hypervirulent (hvKp) is an underrecognized pathotype of since the majority of cases have occurred in East Asia. However, hvKp is a public health threat due to its ability to infect healthy individuals, ongoing dissemination, and acquisition of resistance determinants. hvKp-directed antivirulence therapy is appealing since it has the potential to minimize resistance selection. The discovery that aerobactin is a critical hvKp-specific virulence factor has made its biosynthetic enzymes attractive targets for the development of small molecule inhibitors. However, identification of additional high value targets is needed to enable a robust countermeasure program for this evolving superbug.

摘要

高毒力肺炎克雷伯菌(hvKp)是一种未得到充分认识的致病型,因为大多数病例发生在东亚。然而,hvKp对公共卫生构成威胁,因其能够感染健康个体、持续传播并获得耐药决定因素。针对hvKp的抗毒力疗法很有吸引力,因为它有可能将耐药性选择降至最低。气杆菌素是hvKp特异性关键毒力因子这一发现,使其生物合成酶成为开发小分子抑制剂的有吸引力的靶点。然而,需要鉴定更多高价值靶点,以便为这种不断演变的超级细菌制定强有力的应对方案。

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