Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Department of Pathology & Legal Medicine, Federal University of Ceará. Rua Cel. Nunes de Melo, 1315 - Rodolfo Teófilo - CEP: 60430-275, Fortaleza, Ceará, Brazil.
Postgraduate Program in Veterinary Sciences, College of Veterinary, State University of Ceará. Av. Dr. Silas Munguba, 1700, Campus do Itaperi, CEP: 60714-903, Fortaleza, Ceará, Brazil.
Future Microbiol. 2019 Apr;14:489-497. doi: 10.2217/fmb-2018-0340. Epub 2019 Apr 29.
This study aimed to evaluate the effects of proton pump inhibitors (PPIs) on growth and melanin production by spp. Minimum inhibitory concentrations (MICs) of omeprazole, esomeprazole, rabeprazole, pantoprazole and lansoprazole against spp. were determined and the effect of PPIs on melanin production was evaluated, in the presence or absence of copper sulfate or glutathione. PPIs showed MICs ranging from 125-1000 μg/ml and decreased melanization by cells. Addition of copper sulfate or gluthatione restored melanogenesis of cells grown in the presence of PPIs. The presence of PPIs and glyphosate decreased copper sulfate toxicity (1 mM). PPIs inhibited melanogenesis of spp., possibly by chelating copper or inhibiting copper ATPase transport.
本研究旨在评估质子泵抑制剂（PPIs）对 spp.生长和黑色素生成的影响。测定了奥美拉唑、埃索美拉唑、雷贝拉唑、泮托拉唑和兰索拉唑对 spp.的最小抑菌浓度（MICs），并评估了在添加硫酸铜或谷胱甘肽的情况下，PPIs 对黑色素生成的影响。PPIs 的 MIC 范围为 125-1000μg/ml，可使细胞黑色素生成减少 。添加硫酸铜或谷胱甘肽可恢复在 PPIs 存在下生长的细胞的黑色素生成。PPIs 和草甘膦的存在降低了硫酸铜的毒性（1mM）。PPIs 抑制了 spp.的黑色素生成，可能是通过螯合铜或抑制铜 ATP 酶转运。
