Department of Public Health, Sport and Nutrition, University of Agder, Kristiansand, Norway.
Department of Epidemiology and Biostatistics, Amsterdam Public Health Institute, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam, The Netherlands.
Scand J Med Sci Sports. 2019 Sep;29(9):1274-1287. doi: 10.1111/sms.13442. Epub 2019 May 28.
The aims of the present systematic review and meta-analysis were to investigate the effect of exercise on maximal oxygen uptake ( ) and to investigate whether exercise frequency, intensity, duration, and volume are associated with changes in among adult patients with cancer undergoing treatment. Medline and Embase through OvidSP were searched to identify randomized controlled trials. Two reviewers extracted data and assessed the risk of bias. The overall effect size and differences in effects for different intensities and frequencies were calculated on change scores and post-intervention data, and the meta-regression of exercise duration and volumes was analyzed using the Comprehensive Meta-Analysis software. Fourteen randomized controlled trials were included in the systematic review, comprising 1332 patients with various cancer types receiving (neo-)adjuvant chemo-, radio-, and/or hormone therapy. Exercise induced beneficial changes in compared to usual care (effect size = 0.46, 95% Confidence Interval = 0.23-0.69). Longer session duration (P = 0.020), and weekly duration (P = 0.010), larger weekly volume (P < 0.001), and shorter intervention duration (P = 0.005) were significantly associated with more beneficial changes in . No differences in effects between subgroups with respect to frequency and intensity were found. In conclusion, exercise has beneficial effects on in patients with cancer undergoing (neo-)adjuvant treatment. As interventions with larger exercise volumes and longer session durations resulted in larger beneficial changes in , exercise frequency, intensity, and duration should be considered carefully for sufficient exercise volume to induce changes in for this patient group.
本系统评价和荟萃分析的目的是调查运动对最大摄氧量（ ）的影响，并探讨运动频率、强度、持续时间和量与接受治疗的成年癌症患者 变化之间的关系。通过 OvidSP 在 Medline 和 Embase 上进行检索以确定随机对照试验。两位审查员提取数据并评估偏倚风险。使用 Comprehensive Meta-Analysis 软件对变化分数和干预后 数据进行总体效应大小和不同强度和频率的效果差异的计算，并对运动持续时间和量的荟萃回归进行分析。本系统评价纳入了 14 项随机对照试验，共纳入了 1332 名接受（新）辅助化疗、放疗和/或激素治疗的各种癌症类型的患者。与常规护理相比，运动可引起 有益变化（效应大小=0.46，95%置信区间=0.23-0.69）。单次疗程持续时间更长（P=0.020），每周持续时间更长（P=0.010），每周运动量更大（P<0.001），干预持续时间更短（P=0.005）与 变化更大呈显著相关。关于频率和强度，在亚组之间未发现效果差异。总之，运动对接受（新）辅助治疗的癌症患者的 有益。由于干预运动量大和单次疗程持续时间长导致 变化更大，因此对于该患者群体，应仔细考虑运动频率、强度和持续时间，以确保有足够的运动量来引起 变化。
