阿弗菌素是生物合成途径中阿弗拉菌素和阿弗菌素之间的黄曲霉毒素B1前体。
Averufanin is an aflatoxin B1 precursor between averantin and averufin in the biosynthetic pathway.
作者信息
McCormick S P, Bhatnagar D, Lee L S
出版信息
Appl Environ Microbiol. 1987 Jan;53(1):14-6. doi: 10.1128/aem.53.1.14-16.1987.
Abstract
Wild-type Aspergillus parasiticus produces, in addition to the colorless aflatoxins, a number of pigmented secondary metabolites. Examination of these pigments demonstrated that a major component was an anthraquinone, averufanin. Radiolabeling studies with [14C]averufanin showed that 23% of the label was incorporated into aflatoxin B1 by the wild type and that 31% of the label was incorporated into O-methylsterigmatocystin by a non-aflatoxin-producing isolate. In similar studies with blocked mutants of A. parasiticus the 14C label from averufanin was accumulated in averufin (72%) and versicolorin A (54%) but not averantin. The results demonstrate that averufanin is a biosynthetic precursor of aflatoxin B1 between averantin and averufin.
摘要
野生型寄生曲霉除了产生无色黄曲霉毒素外，还产生多种有色次生代谢产物。对这些色素的检测表明，主要成分是一种蒽醌，即疣孢青霉醌。用[14C]疣孢青霉醌进行的放射性标记研究表明，野生型将23%的标记物掺入黄曲霉毒素B1中，而一个不产生黄曲霉毒素的分离株将31%的标记物掺入O-甲基柄曲霉素中。在对寄生曲霉阻断突变体的类似研究中，来自疣孢青霉醌的14C标记物积累在疣孢菌素（72%）和杂色曲霉素A（54%）中，但未积累在疣孢青霉醇中。结果表明，疣孢青霉醌是黄曲霉毒素B1在疣孢青霉醇和疣孢菌素之间的生物合成前体。
相似文献
1
Averufanin is an aflatoxin B1 precursor between averantin and averufin in the biosynthetic pathway.阿弗菌素是生物合成途径中阿弗拉菌素和阿弗菌素之间的黄曲霉毒素B1前体。
Appl Environ Microbiol. 1987 Jan;53(1):14-6. doi: 10.1128/aem.53.1.14-16.1987.
2
Identification of averantin as an aflatoxin B1 precursor: placement in the biosynthetic pathway.鉴定averantin为黄曲霉毒素B1前体：确定其在生物合成途径中的位置。
Appl Environ Microbiol. 1980 Apr;39(4):835-9. doi: 10.1128/aem.39.4.835-839.1980.
3
avnA, a gene encoding a cytochrome P-450 monooxygenase, is involved in the conversion of averantin to averufin in aflatoxin biosynthesis in Aspergillus parasiticus.avnA是一种编码细胞色素P-450单加氧酶的基因，参与寄生曲霉黄曲霉毒素生物合成过程中averantin向averufin的转化。
Appl Environ Microbiol. 1997 Apr;63(4):1349-56. doi: 10.1128/aem.63.4.1349-1356.1997.
4
Yellow pigments used in rapid identification of aflatoxin-producing Aspergillus strains are anthraquinones associated with the aflatoxin biosynthetic pathway.用于快速鉴定产黄曲霉毒素曲霉菌株的黄色色素是与黄曲霉毒素生物合成途径相关的蒽醌类物质。
Bioorg Chem. 2005 Dec;33(6):426-38. doi: 10.1016/j.bioorg.2005.09.002. Epub 2005 Nov 2.
5
Precursor recognition by kinetic pulse-labeling in a toxigenic aflatoxin B1-producing strain of Aspergillus.在产毒黄曲霉毒素B1的黄曲霉菌株中通过动力学脉冲标记进行前体识别。
Appl Environ Microbiol. 1981 Jul;42(1):168-73. doi: 10.1128/aem.42.1.168-173.1981.
6
Mode of action of pesticides on aflatoxin biosynthesis and oxidase system activity.农药对黄曲霉毒素生物合成及氧化酶系统活性的作用方式。
Microbiol Res. 1999 May;154(1):95-102. doi: 10.1016/S0944-5013(99)80041-X.
7
Identification of O-methylsterigmatocystin as an aflatoxin B1 and G1 precursor in Aspergillus parasiticus.鉴定寄生曲霉中O-甲基柄曲霉素作为黄曲霉毒素B1和G1的前体。
Appl Environ Microbiol. 1987 May;53(5):1028-33. doi: 10.1128/aem.53.5.1028-1033.1987.
8
Biosynthesis of aflatoxin B1. Conversion of versicolorin A to aflatoxin B1 by Aspergillus parasiticus.黄曲霉毒素B1的生物合成。寄生曲霉将杂色曲霉素A转化为黄曲霉毒素B1。
J Agric Food Chem. 1976 Nov-Dec;24(6):1167-70. doi: 10.1021/jf60208a017.
9
Enzymatic conversion of norsolorinic acid to averufin in aflatoxin biosynthesis.黄曲霉毒素生物合成中诺索尔紫红质酸向奥佛尼菌素的酶促转化。
Appl Environ Microbiol. 1991 May;57(5):1340-5. doi: 10.1128/aem.57.5.1340-1345.1991.
10
Influence of white light on production of aflatoxins and anthraquinones in Aspergillus parasiticus.白光对寄生曲霉中黄曲霉毒素和蒽醌产生的影响。
Appl Environ Microbiol. 1981 Feb;41(2):488-91. doi: 10.1128/aem.41.2.488-491.1981.
引用本文的文献
1
Mixtures of Mycotoxins, Phytoestrogens, and Other Secondary Metabolites in Whole-Plant Corn Silages and Total Mixed Rations of Dairy Farms in Central and Northern Mexico.中北美奶牛养殖场全株青贮玉米和全混合日粮中的真菌毒素、植物雌激素和其他次生代谢物混合物。
Toxins (Basel). 2023 Feb 13;15(2):153. doi: 10.3390/toxins15020153.
2
Mycotoxins, Phytoestrogens and Other Secondary Metabolites in Austrian Pastures: Occurrences, Contamination Levels and Implications of Geo-Climatic Factors.奥地利牧场中的真菌毒素、植物雌激素和其他次生代谢物：地理气候因素的发生、污染水平和影响。
Toxins (Basel). 2021 Jun 30;13(7):460. doi: 10.3390/toxins13070460.
3
Current understanding on aflatoxin biosynthesis and future perspective in reducing aflatoxin contamination.当前关于黄曲霉毒素生物合成的认识及降低黄曲霉毒素污染的未来展望。
Toxins (Basel). 2012 Oct 25;4(11):1024-57. doi: 10.3390/toxins4111024.
4
Absence of the aflatoxin biosynthesis gene, norA, allows accumulation of deoxyaflatoxin B1 in Aspergillus flavus cultures.缺乏黄曲霉毒素生物合成基因 norA 可导致黄曲霉培养物中脱氧黄曲霉毒素 B1 的积累。
FEMS Microbiol Lett. 2010 Apr;305(1):65-70. doi: 10.1111/j.1574-6968.2010.01914.x. Epub 2010 Jan 27.
5
Involvement of two cytosolic enzymes and a novel intermediate, 5'-oxoaverantin, in the pathway from 5'-hydroxyaverantin to averufin in aflatoxin biosynthesis.在黄曲霉毒素生物合成中，两种胞质酶和一种新型中间体5'-氧杂averantin参与了从5'-羟基averantin到averufin的途径。
Appl Environ Microbiol. 2003 Nov;69(11):6418-26. doi: 10.1128/AEM.69.11.6418-6426.2003.
6
adhA in Aspergillus parasiticus is involved in conversion of 5'-hydroxyaverantin to averufin.寄生曲霉中的adhA参与了5'-羟基averantin向averufin的转化。
Appl Environ Microbiol. 2000 Nov;66(11):4715-9. doi: 10.1128/AEM.66.11.4715-4719.2000.
7
Requirement of monooxygenase-mediated steps for sterigmatocystin biosynthesis by Aspergillus nidulans.构巢曲霉生物合成柄曲霉素过程中对单加氧酶介导步骤的需求
Appl Environ Microbiol. 2000 Jan;66(1):359-62. doi: 10.1128/AEM.66.1.359-362.2000.
8
avnA, a gene encoding a cytochrome P-450 monooxygenase, is involved in the conversion of averantin to averufin in aflatoxin biosynthesis in Aspergillus parasiticus.avnA是一种编码细胞色素P-450单加氧酶的基因，参与寄生曲霉黄曲霉毒素生物合成过程中averantin向averufin的转化。
Appl Environ Microbiol. 1997 Apr;63(4):1349-56. doi: 10.1128/aem.63.4.1349-1356.1997.
9
Identification of aflatoxin biosynthesis genes by genetic complementation in an Aspergillus flavus mutant lacking the aflatoxin gene cluster.通过在缺乏黄曲霉毒素基因簇的黄曲霉突变体中进行遗传互补来鉴定黄曲霉毒素生物合成基因。
Appl Environ Microbiol. 1996 Oct;62(10):3567-71. doi: 10.1128/aem.62.10.3567-3571.1996.
10
Purification of a 40-kilodalton methyltransferase active in the aflatoxin biosynthetic pathway.纯化在黄曲霉毒素生物合成途径中具有活性的一种40千道尔顿甲基转移酶。
Appl Environ Microbiol. 1993 Feb;59(2):479-84. doi: 10.1128/aem.59.2.479-484.1993.
本文引用的文献
1
INCORPORATION OF LABELLED COMPOUNDS INTO AFLATOXINS.标记化合物掺入黄曲霉毒素中。
Biochim Biophys Acta. 1964 May 11;86:418-20. doi: 10.1016/0304-4165(64)90077-7.
2
Identification of averantin as an aflatoxin B1 precursor: placement in the biosynthetic pathway.鉴定averantin为黄曲霉毒素B1前体：确定其在生物合成途径中的位置。
Appl Environ Microbiol. 1980 Apr;39(4):835-9. doi: 10.1128/aem.39.4.835-839.1980.
3
New perspectives on aflatoxin biosynthesis.黄曲霉毒素生物合成的新视角。
Adv Appl Microbiol. 1983;29:53-92. doi: 10.1016/s0065-2164(08)70354-x.
4
Norsolorinic acid from a mutant strain of Aspergillus parasiticus.来自寄生曲霉突变株的降红青霉素酸。
J Am Oil Chem Soc. 1971 Feb;48(2):93-4. doi: 10.1007/BF02635696.
5
Isolation of averufin from a mutant of Aspergillus parasiticus impaired in aflatoxin biosynthesis.从黄曲霉毒素生物合成受损的寄生曲霉突变体中分离出黄绿青霉素。
Biochem Biophys Res Commun. 1972 Jun 9;47(5):1051-5. doi: 10.1016/0006-291x(72)90939-4.
6
Step of dichlorvos inhibition in the pathway of aflatoxin biosynthesis.敌敌畏在黄曲霉毒素生物合成途径中的抑制步骤。
Appl Microbiol. 1974 Jul;28(1):52-7. doi: 10.1128/am.28.1.52-57.1974.
7
Conversion of averufin into aflatoxins by Aspergillus parasiticus.寄生曲霉将黄绿青霉素转化为黄曲霉毒素。
Biochemistry. 1973 Dec 4;12(25):5167-71. doi: 10.1021/bi00749a023.
8
Averufin in the biosynthesis of aflatoxin B.阿弗菌素在黄曲霉毒素B的生物合成中。
J Am Chem Soc. 1973 Mar 7;95(5):1668-9. doi: 10.1021/ja00786a056.
9
Biosynthetic relationship among aflatoxins B1, B2, M1, and M2.黄曲霉毒素B1、B2、M1和M2之间的生物合成关系。
Appl Environ Microbiol. 1985 Jun;49(6):1392-5. doi: 10.1128/aem.49.6.1392-1395.1985.
10
Synthesis of versicolorin A by a mutant strain of Aspergillus parasiticus deficient in aflatoxin production.由黄曲霉毒素产生缺陷型寄生曲霉突变株合成杂色曲霉素A。
J Agric Food Chem. 1975 Nov-Dec;23(6):1132-4. doi: 10.1021/jf60202a011.
Zotero 插件