Suppr超能文献

一女孩被狂犬袭击致面神经损伤,虽及时进行了暴露后预防处理,但仍发病,考虑狂犬病毒可能经损伤的面神经直接进入。

Failure of postexposure prophylaxis in a girl child attacked by rabid dog severing her facial nerve causing possible direct entry of rabies virus into the facial nerve.

机构信息

State Epidemiologist, State Institute of Health & Family Welfare, Shimla, Himachal Pradesh, India.

Department of Health & Family Welfare, Civil Hospital Theog, Shimla, Himachal Pradesh, India.

出版信息

Hum Vaccin Immunother. 2019;15(11):2612-2614. doi: 10.1080/21645515.2019.1608131. Epub 2019 May 22.

Abstract

On January 4, 2019 an eight-year-old girl child was bitten by a suspected rabid dog over the left parotid region. After a 17-h delay, the child was brought for rabies postexposure prophylaxis (PEP) at Civil Hospital Theog and was administered complete PEP. On January 29, 2019, the child was again brought to Theog Hospital with complaints of having fever, difficulty in walking, neck drop, and ptosis. On examination, pediatrician found photophobia, phonophobia, and hydrophobia and subsequently the patient died of cardiac arrest. On postmortem examination, the facial nerve was found dissected and injured at the inner end of the parotid gland. A severed end toward the brain was swollen and edematous. The entire brain was extracted and sent to Central Research Institute Kasauli for confirmation of rabies, where it tested positive for rabies by Fluorescent Antibodies Test and Biological Test. In situations where sensitive parts such as the face are involved, a thorough wound wash with soap and water and application of antiseptics along with immediate PEP may save some lives by not allowing the virus enough time to attach to and infect the nerve cells.

摘要

2019 年 1 月 4 日,一名 8 岁女童左侧腮腺区被疑似狂犬病犬咬伤。伤后 17 小时才到蒂罗格镇立医院接受狂犬病暴露后预防(PEP),并接受了完整的 PEP。2019 年 1 月 29 日,该女童再次因发热、行走困难、颈部下垂和上睑下垂到蒂罗格医院就诊。儿科医生在检查时发现了畏光、恐声和恐水症,随后该患者死于心脏骤停。尸检发现面神经在腮腺内端被切开和损伤。朝向大脑的一端肿胀和水肿。整个大脑被提取出来并送往卡索利中央研究所进行狂犬病确认,荧光抗体试验和生物学试验均证实为狂犬病阳性。在面部等敏感部位受伤的情况下,彻底用肥皂和水冲洗伤口,并使用防腐剂,同时立即进行 PEP,可以为患者争取时间,阻止病毒附着并感染神经细胞,从而挽救一些生命。

相似文献

10
Rabies encephalitis in a preschool child following postexposure prophylaxis.幼儿在暴露后预防后发生狂犬病脑炎。
PLoS Negl Trop Dis. 2021 Feb 18;15(2):e0009045. doi: 10.1371/journal.pntd.0009045. eCollection 2021 Feb.

本文引用的文献

1
Modelling to inform prophylaxis regimens to prevent human rabies.建立模型以确定预防人类狂犬病的预防方案。
Vaccine. 2019 Oct 3;37 Suppl 1(Suppl 1):A166-A173. doi: 10.1016/j.vaccine.2018.11.010. Epub 2018 Dec 7.
2
Rabies.狂犬病。
Nat Rev Dis Primers. 2017 Nov 30;3:17091. doi: 10.1038/nrdp.2017.91.
5
Pre-exposure rabies prophylaxis: a systematic review.暴露前狂犬病预防:一项系统评价
Bull World Health Organ. 2017 Mar 1;95(3):210-219C. doi: 10.2471/BLT.16.173039. Epub 2016 Nov 25.
7
Estimating the global burden of endemic canine rabies.估算地方性犬类狂犬病的全球负担。
PLoS Negl Trop Dis. 2015 Apr 16;9(4):e0003709. doi: 10.1371/journal.pntd.0003709. eCollection 2015 Apr.
10
Failures of post-exposure rabies prophylaxis.暴露后狂犬病预防失败。
Vaccine. 2007 Nov 1;25(44):7605-9. doi: 10.1016/j.vaccine.2007.08.054. Epub 2007 Sep 14.

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验