Fligor Brian J
Tobias and Battite, Inc., Boston, Massachusetts.
Lantos Technologies, Inc., Wilmington, Massachusetts.
Semin Hear. 2019 May;40(2):154-161. doi: 10.1055/s-0039-1684044. Epub 2019 Apr 26.
Medical interventions to combat serious infection or malignancies carry significant morbidities, including ototoxicity. While these lifesaving drugs are often necessary to preserve life, the impact on quality of life for survivors is increasingly concerning for families and healthcare providers. Of primary importance for medical prescribers are appropriately sensitive ototoxicity grading scales and audiological monitoring protocols for surveillance for hearing loss. The intent of grading scales is to help communicate complicated audiological information to non-audiologist healthcare providers (such as oncologists) to help them make good decisions with regards to chemotherapy dosing. Appropriate audiological monitoring helps reduce the time delay between the adventitious onset of hearing loss and the diagnosis and intervention. Finally, pediatric ototoxicity grading and monitoring protocols help ensure timely access to adequate hearing habilitation, verification and validation of the management of permanent medication-induced hearing loss and tinnitus in children.
对抗严重感染或恶性肿瘤的医学干预措施会带来重大的发病率，包括耳毒性。虽然这些挽救生命的药物通常对于维持生命是必要的，但对于幸存者生活质量的影响越来越受到家庭和医疗服务提供者的关注。对于开处方的医生来说，最重要的是要有适当敏感的耳毒性分级量表和听力监测方案，以监测听力损失。分级量表的目的是帮助向非听力学家的医疗服务提供者（如肿瘤学家）传达复杂的听力信息，以帮助他们就化疗剂量做出明智的决定。适当的听力监测有助于减少听力损失偶然发生与诊断和干预之间的时间延迟。最后，儿科耳毒性分级和监测方案有助于确保及时获得适当的听力康复，验证和确认儿童永久性药物性听力损失和耳鸣的管理。
