Peyvandi Ali Azghar, Okhovatian Farshad, Rezaei Tavirani Majid, Zamanian Azodi Mona, Rezaei Tavirani Mostafa
Hearing Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Physiotherapy Research Centre, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Child Neurol. 2019 Spring;13(2):125-134.
Becker Muscular Dystrophy (BMD) is a neuromuscular disorder which is incurable. In this research protein interaction network of most associated proteins with BMD to provide better clarification of disorder underlying mechanism was investigated.
MATERIALS & METHODS: The related genes to BMD were retrieved via string database and conducted by Cytoscape and the related algorithms. The network centrality analysis was performed based on degree, betweenness, closeness, and stress parameters. Gene ontology and clustering were performed via ClueGO analysis.
DMD as the super-hub as well as other central proteins including UTRN, TTN, DNM2, and RYR1 are important in BMD in terms of interactive features. The impairment of muscular contraction may be vital in BMD disease pathogenesis as it is the highlighted biological process term obtained by ClueGO analysis.
DMD targeting may be the main concern for dystrophy clinical approaches. However, the other suggested proteins should be evaluated. Targeting these key proteins are required for treatment goals following extensive validation studies.
贝克尔肌营养不良症（BMD）是一种无法治愈的神经肌肉疾病。本研究调查了与BMD最相关蛋白质的蛋白质相互作用网络，以更好地阐明该疾病的潜在机制。
通过STRING数据库检索与BMD相关的基因，并利用Cytoscape及相关算法进行分析。基于度、介数、紧密性和应力参数进行网络中心性分析。通过ClueGO分析进行基因本体论和聚类分析。
DMD作为超级中心节点以及其他中心蛋白，包括UTRN、TTN、DNM2和RYR1，在BMD的相互作用特征方面具有重要意义。肌肉收缩受损在BMD疾病发病机制中可能至关重要，因为这是通过ClueGO分析获得的突出生物学过程术语。
靶向DMD可能是肌营养不良症临床治疗方法的主要关注点。然而，其他建议的蛋白质也应进行评估。在经过广泛的验证研究后，靶向这些关键蛋白质对于治疗目标是必要的。
