髋关节重度骨关节炎患者的血管细胞黏附分子1：一项前瞻性横断面研究。
Vascular cell adhesion molecule 1 in patients with severe osteoarthritis of the hip : A prospective cross-sectional study.
作者信息
Oppl Bastian, Datz Christian, Huber-Schönauer Ursula, Husar-Memmer Emma, Brozek Wolfgang, Zenz Peter, Gollob Eva, Wurnig Christian, Engel Alfred, Klaushofer Klaus, Zwerina Jochen, Bartko Johann
机构信息
1st Medical Department, Hanusch Hospital, Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, Heinrich Collin-Str. 30, 1140, Vienna, Austria.
Department of Internal Medicine, Hospital Oberndorf, Teaching Hospital of the Paracelsus Private Medical University of Salzburg, Oberndorf, Austria.
出版信息
Wien Klin Wochenschr. 2019 Aug;131(15-16):369-373. doi: 10.1007/s00508-019-1497-2. Epub 2019 Apr 29.
BACKGROUND
Osteoarthritis (OA) of the hip is a frequent and debilitating joint disease. Only few clinical risk factors for hip OA are established and clinically applicable biomarkers to identify patients at risk are still lacking. The glycoprotein vascular cell adhesion molecule 1 (VCAM-1) is expressed by chondrocytes and synovial tissue and was a predictive marker for development of severe large joint OA in a previous study.
OBJECTIVE
It was tested whether increased serum levels of VCAM-1 are prevalent in patients with severe OA of the hips.
METHODS
In this prospective, multicenter, cross-sectional study, risk factors of severe hip OA were investigated in patients scheduled for hip joint arthroplasty and 100 patients were randomly selected for validation of VCAM-1 as a potential biomarker for hip OA. Serum samples were analyzed by an enzyme-linked immunosorbent assay and compared with a sex and age-matched control cohort.
RESULTS
The groups were similar in age, gender ratio and prevalence of diabetes. Serum concentrations of VCAM-1 were 8% higher in OA patients compared to controls, without reaching statistical significance (818 ng ml, 95% confidence interval, CI 746-891 ng ml versus 759 ng m, 95% CI 711-807 ng ml; P = 0.4839).
CONCLUSION
The results of this study show that serum concentrations of VCAM-1 cannot distinguish patients with severe hip OA from age and sex-matched controls.
背景
髋关节骨关节炎（OA）是一种常见且使人衰弱的关节疾病。目前仅确定了少数髋关节OA的临床风险因素，且仍缺乏可用于识别高危患者的临床适用生物标志物。糖蛋白血管细胞黏附分子1（VCAM-1）由软骨细胞和滑膜组织表达，在先前的一项研究中是严重大关节OA发展的预测标志物。
目的
检测血清VCAM-1水平升高在重度髋关节OA患者中是否普遍存在。
方法
在这项前瞻性、多中心横断面研究中，对计划进行髋关节置换术的患者调查重度髋关节OA的危险因素，并随机选择100例患者以验证VCAM-1作为髋关节OA潜在生物标志物的情况。通过酶联免疫吸附测定法分析血清样本，并与性别和年龄匹配的对照队列进行比较。
结果
两组在年龄、性别比例和糖尿病患病率方面相似。OA患者血清VCAM-1浓度比对照组高8%，但未达到统计学显著性（818 ng/ml，95%置信区间，CI 746 - 891 ng/ml，而对照组为759 ng/ml，95% CI 711 - 807 ng/ml；P = 0.4839）。
结论
本研究结果表明，血清VCAM-1浓度无法区分重度髋关节OA患者与年龄和性别匹配的对照组。
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