主要多酚对橄榄油叶抗氧化特性和细胞毒性活性的贡献。
Contribution of Major Polyphenols to the Antioxidant Profile and Cytotoxic Activity of Olive Leaves.
机构信息
Environmental Bioprocesses Laboratory, Centre of Biotechnology of Sfax. P.O. Box «1177». Sfax 3018, Tunisia.
Alliance for Research on North Africa (ARENA), University of Tsukuba. 1-1-1 Tennodai. Tsukuba. Ibaraki 305-8572, Japan.
出版信息
Anticancer Agents Med Chem. 2019;19(13):1651-1657. doi: 10.2174/1871520619666190416101622.
AIMS
This study was designed to investigate the phytochemical profile and the cytotoxic activities of the eco-friendly extracts of olive leaves from cultivar.
MATERIALS AND METHODS
The Phenolic composition of olive leaves extracts, the antioxidant activity and the cytotoxic effects against MCF-7 and HepG2 cells were determined.
RESULTS
Olive leaves extracts showed relevant total polyphenols contents. Oleuropein was the major detected phenolic compound reaching a concentration of 16.9 mg/ml. The antioxidant potential of the studied extracts varied from 23.7 to 46.5mM Trolox equivalents as revealed by DPPH and ABTS assays. Cytotoxicity experiments showed similar trends for both HepG2 and MCF-7 cells with the infusion extract being the most active.
CONCLUSION
This study denotes that olive leaves may have great potential as endless bioresource of valuable bioactive compounds which may have a wide application.
目的
本研究旨在探究品种橄榄叶的生态友好型提取物的植物化学成分谱和细胞毒性活性。
材料与方法
测定了橄榄叶提取物的酚类成分、抗氧化活性以及对 MCF-7 和 HepG2 细胞的细胞毒性作用。
结果
橄榄叶提取物表现出相关的总多酚含量。橄榄苦苷是主要检测到的酚类化合物，浓度达到 16.9mg/ml。通过 DPPH 和 ABTS 测定法显示，研究提取物的抗氧化潜力从 23.7 到 46.5mM 生育酚当量不等。细胞毒性实验表明，两种 HepG2 和 MCF-7 细胞的趋势相似，输液提取物最为活跃。
结论
本研究表明，橄榄叶可能具有作为有价值生物活性化合物无尽生物资源的巨大潜力，这些化合物可能具有广泛的应用。
Zotero 插件