Migliori Giovanni Battista, Centis Rosella, D'Ambrosio Lia, Silva Denise Rossato, Rendon Adrian
. Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri - IRCCS - Tradate, Italia.
. Public Health Consulting Group, Lugano, Switzerland.
J Bras Pneumol. 2019 Apr 25;45(2):e20180420. doi: 10.1590/1806-3713/e20180420.
Most studies of tuberculosis originate from high-income countries with a low incidence of tuberculosis. A review of the scientific production on tuberculosis in Latin American countries, most of which are low- or middle-income countries (some with high or intermediate tuberculosis incidence rates), would improve the understanding of public health challenges, clinical needs, and research priorities. The aims of this systematic review were to determine what has been published recently in Latin America, to identify the leading authors involved, and to quantify the impact of international collaborations.
We used PubMed to identify relevant manuscripts on pulmonary tuberculosis (PTB), drug-resistant tuberculosis (DR-TB), or multidrug-resistant tuberculosis (MDR-TB), published between 2013 and 2018. We selected only studies conducted in countries with an annual tuberculosis incidence of ≥ 10,000 reported cases and an annual MDR-TB incidence of ≥ 300 estimated cases, including Brazil, Peru, Mexico, Colombia, and Argentina. Articles were stratified by country, type, and topic.
We identified as eligible 395 studies on PTB and 188 studies on DR/MDR-TB-of which 96.4% and 96.8%, respectively, were original studies; 35.5% and 32.4%, respectively, had an epidemiological focus; and 52.7% and 36.2%, respectively, were conducted in Brazil. The recent Latin American Thoracic Association/European Respiratory Society/Brazilian Thoracic Association collaborative project boosted the production of high-quality articles on PTB and DR/MDR-TB in Latin America.
Most of the recent Latin American studies on tuberculosis were conducted in Brazil, Mexico, or Peru. Collaboration among medical societies facilitates the production of scientific papers on tuberculosis. Such initiatives are in support of the World Health Organization call for intensified research and innovation in tuberculosis.
大多数结核病研究来自结核病发病率较低的高收入国家。回顾拉丁美洲国家（其中大多数是低收入或中等收入国家，有些国家结核病发病率较高或处于中等水平）关于结核病的科研成果，将有助于增进对公共卫生挑战、临床需求和研究重点的理解。本系统评价的目的是确定拉丁美洲最近发表了哪些研究，找出主要作者，并量化国际合作的影响。
我们使用PubMed检索2013年至2018年间发表的关于肺结核（PTB）、耐药结核病（DR-TB）或耐多药结核病（MDR-TB）的相关手稿。我们仅选择在年结核病报告病例数≥10000例且年耐多药结核病估计病例数≥300例的国家开展的研究，包括巴西、秘鲁、墨西哥、哥伦比亚和阿根廷。文章按国家、类型和主题进行分层。
我们确定了395项关于肺结核的研究和188项关于耐多药/耐多药结核病的研究，其中分别有96.4%和96.8%是原创研究；分别有35.5%和32.4%以流行病学为重点；分别有52.7%和36.2%在巴西进行。最近拉丁美洲胸科学会/欧洲呼吸学会/巴西胸科学会的合作项目促进了拉丁美洲关于肺结核和耐多药/耐多药结核病的高质量文章的发表。
最近拉丁美洲关于结核病的研究大多在巴西、墨西哥或秘鲁进行。医学学会之间的合作有助于结核病科学论文的发表。这些举措支持了世界卫生组织关于加强结核病研究和创新的呼吁。
