1 Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
2 Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Otolaryngol Head Neck Surg. 2019 Sep;161(3):539-542. doi: 10.1177/0194599819847152. Epub 2019 Apr 30.
While optical imaging with near-infrared (NIR) fluorescent dye has been used in oncologic surgery, its use in the head and neck has not been established. We aimed to evaluate the feasibility of using NIR to visualize primary tumor and regional metastasis in head and neck malignancy. Patients undergoing resection of primary head and neck tumors were included in this pilot study. Each patient was injected with indocyanine green dye (ICG) the day prior to surgery. The VisionSense Iridium camera system was used to visualize the primary lesion, its margins, and neck dissection specimen intraoperatively. Fourteen patients were enrolled. Eighty-six percent of primary tumors showed fluorescence as compared with surrounding tissues. ICG positivity showed 100% sensitivity for pathologic nodes in 7 neck dissection specimens; however, for 3 patients, nonpathologic nodes also showed ICG positivity. NIR imaging with ICG dye can be considered for intraoperative imaging of head and neck lesions.
虽然近红外（NIR）荧光染料的光学成像是用于肿瘤外科手术中的，但它在头颈部的应用尚未确定。我们旨在评估使用 NIR 可视化头颈部恶性肿瘤原发肿瘤和区域转移的可行性。本研究纳入了接受头颈部原发肿瘤切除术的患者。每位患者在手术前一天注射吲哚菁绿染料（ICG）。术中使用 VisionSense Iridium 摄像系统可视化原发灶及其边缘和颈部清扫标本。共纳入 14 例患者。与周围组织相比，86%的原发肿瘤显示荧光。7 个颈部清扫标本中，ICG 阳性对病理淋巴结的灵敏度为 100%；然而，对于 3 名患者，非病理淋巴结也显示 ICG 阳性。可以考虑使用 ICG 染料的近红外成像进行头颈部病变的术中成像。
